Clinical usefulness of FDG-PET/CT scan imaging in the management of posttransplant lymphoproliferative disease.

Détails

ID Serval
serval:BIB_84FDFA6A2731
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Clinical usefulness of FDG-PET/CT scan imaging in the management of posttransplant lymphoproliferative disease.
Périodique
Transplantation
Auteur(s)
Bianchi E., Pascual M., Nicod M., Delaloye A.B., Duchosal M.A.
ISSN
0041-1337
Statut éditorial
Publié
Date de publication
2008
Peer-reviewed
Oui
Volume
85
Numéro
5
Pages
707-712
Langue
anglais
Notes
Publication types: Case Reports ; Journal Article
Résumé
BACKGROUND: Posttransplant lymphoproliferative disease (PTLD) is, aside skin cancer, the most common malignancy occurring after solid organ transplant in adults. Fluorodeoxyglucose (FDG) positron emission tomography (PET) has proved useful in the management of lymphomas. METHODS: We report our experience with the use of FDG-PET inline with computed tomography (CT) scanning in the management of four transplant recipients with histologically confirmed PTLD, including three monomorphic PTLDs and one polymorphic PTLD. RESULTS: FDG-PET/CT scan at diagnosis showed increased FDG uptake in all examined PTLD lesions, and the disease was upstaged on the basis of FDG-PET/CT scan results over conventional CT scanning in one patient. At the end of treatment, PET/CT scans no longer demonstrated FDG uptake in the original PTLD lesions in all patients. Complete remission of disease persisted for at least 1 year after diagnosis in all. CONCLUSIONS: Our results strongly support that FDG-PET scanning is highly specific for diagnosis and follow-up of PTLD. The clinical relevance of including FDG-PET/CT scanning in the management of PTLD should be evaluated in a larger prospective cohort study.
Mots-clé
Adult, Fluorodeoxyglucose F18/diagnostic use, Humans, Immunosuppressive Agents/therapeutic use, Kidney Transplantation/adverse effects, Kidney Transplantation/immunology, Lymphoproliferative Disorders/radiography, Lymphoproliferative Disorders/radionuclide imaging, Middle Aged, Positron-Emission Tomography, Postoperative Complications/radiography, Postoperative Complications/radionuclide imaging, Radiopharmaceuticals/diagnostic use, Tomography, X-Ray Computed
Pubmed
Web of science
Création de la notice
29/01/2009 23:12
Dernière modification de la notice
05/03/2018 10:48
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