Endogenous glucose production, gluconeogenesis and liver glycogen concentration in obese non-diabetic patients

Détails

ID Serval
serval:BIB_84F85E7BBF28
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Endogenous glucose production, gluconeogenesis and liver glycogen concentration in obese non-diabetic patients
Périodique
Diabetologia
Auteur(s)
Muller  C., Assimacopoulos-Jeannet  F., Mosimann  F., Schneiter  P., Riou  J. P., Pachiaudi  C., Felber  J. P., Jequier  E., Jeanrenaud  B., Tappy  L.
ISSN
0012-186X (Print)
Statut éditorial
Publié
Date de publication
04/1997
Volume
40
Numéro
4
Pages
463-8
Notes
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Apr
Résumé
Resting, post-absorptive endogenous glucose production (EGP), fractional gluconeogenesis and liver glycogen concentration were assessed in 6 lean and 5 obese non-diabetic subjects undergoing elective abdominal surgery. During the 2 days preceding these measurements, 0.3 g/day U-13C glucose had been added to their usual diet to label their endogenous glycogen stores. On the morning of day 3, EGP was measured with 6,6-2H glucose. Their endogenous 13C glycogen enrichment was calculated from 13CO2 and respiratory gas exchanges. Fractional gluconeogenesis was assessed as 1-(13C glucose/13C glycogen)100. EGP was similar in lean subjects (113 +/- 5 mg/min) and in obese subjects (111 +/- 6). Fractional gluconeogenesis was higher in obese (59 +/- 10%) than in lean subjects (29 +/- 8%). However, overall EGP remained constant due to a decrease in glycogenolysis. Since an increased gluconeogenesis and a decreased glycogenolysis may both contribute to increase liver glycogen concentration in obesity, hepatic glycogen concentrations were assessed in hepatic needle biopsies obtained during surgery. Hepatic glycogen concentrations were increased in obese patients (515 +/- 38 mg/g protein) compared to lean subjects (308 +/- 58, p < 0.05). It is concluded that in obese patients: a) fractional gluconeogenesis is increased; b) overall EGP is unchanged due to a proportional inhibition of glycogenolysis; c) liver glycogen concentration is increased.
Mots-clé
Adult Aged Biopsy Blood Glucose/metabolism Body Mass Index Carbon Isotopes Fatty Acids, Nonesterified/blood Female Glucagon/blood *Gluconeogenesis Glucose/*metabolism Humans Insulin/blood Liver/*metabolism/pathology Liver Glycogen/biosynthesis/*metabolism Male Middle Aged Models, Biological Obesity/*metabolism Reference Values Thinness/metabolism
Pubmed
Web of science
Création de la notice
24/01/2008 14:36
Dernière modification de la notice
03/03/2018 18:56
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