Localized in vivo hyperpolarization transfer sequences.

Détails

ID Serval
serval:BIB_84C794E9FBDF
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Localized in vivo hyperpolarization transfer sequences.
Périodique
Magnetic Resonance in Medicine
Auteur(s)
Mishkovsky M., Cheng T., Comment A., Gruetter R.
ISSN
1522-2594 (Electronic)
ISSN-L
0740-3194
Statut éditorial
Publié
Date de publication
2012
Volume
68
Numéro
2
Pages
349-352
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish. PDF type: Note
Résumé
In vivo localized and fully adiabatic homonuclear and heteronuclear polarization transfer experiments were designed and performed in the rat brain at 9.4 T after infusion of hyperpolarized sodium [1,2-(13)C(2)] and sodium [1-(13)C] acetate. The method presented herein leads to highly enhanced in vivo detection of short-T(1) (13)C as well as attached protons. This indirect detection scheme allows for probing additional molecular sites in hyperpolarized substrates and their metabolites and can thus lead to improved spectral resolution such as in the case of (13)C-acetate metabolism.
Mots-clé
Acetates/analysis, Algorithms, Animals, Brain/metabolism, Nuclear Magnetic Resonance, Biomolecular/methods, Rats, Rats, Sprague-Dawley, Reproducibility of Results, Sensitivity and Specificity, Signal Processing, Computer-Assisted, Tissue Distribution
Pubmed
Web of science
Création de la notice
29/04/2013 10:41
Dernière modification de la notice
03/03/2018 18:55
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