A photopolymerized composite hydrogel and surgical implanting tool for a nucleus pulposus replacement.

Détails

ID Serval
serval:BIB_84C773C5F33D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
A photopolymerized composite hydrogel and surgical implanting tool for a nucleus pulposus replacement.
Périodique
Biomaterials
Auteur(s)
Schmocker A., Khoushabi A., Frauchiger D.A., Gantenbein B., Schizas C., Moser C., Bourban P.E., Pioletti D.P.
ISSN
1878-5905 (Electronic)
ISSN-L
0142-9612
Statut éditorial
Publié
Date de publication
2016
Peer-reviewed
Oui
Volume
88
Pages
110-119
Langue
anglais
Résumé
Nucleus pulposus replacements have been subjected to highly controversial discussions over the last 40 years. Their use has not yet resulted in a positive outcome to treat herniated disc or degenerated disc disease. The main reason is that not a single implant or tissue replacement was able to withstand the loads within an intervertebral disc. Here, we report on the development of a photo-polymerizable poly(ethylene glycol)dimethacrylate nano-fibrillated cellulose composite hydrogel which was tuned according to native tissue properties. Using a customized minimally-invasive medical device to inject and photopolymerize the hydrogel insitu, samples were implanted through an incision of 1 mm into an intervertebral disc of a bovine organ model to evaluate their long-term performance. When implanted into the bovine disc model, the composite hydrogel implant was able to significantly re-establish disc height after surgery (p < 0.0025). The height was maintained after 0.5 million loading cycles (p < 0.025). The mechanical resistance of the novel composite hydrogel material combined with the minimally invasive implantation procedure into a bovine disc resulted in a promising functional orthopedic implant for the replacement of the nucleus pulposus.
Pubmed
Web of science
Création de la notice
22/03/2016 19:37
Dernière modification de la notice
03/03/2018 18:55
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