Successful Serology-Based Intervention to Increase Protection against Vaccine-Preventable Diseases in Liver Transplanted Children: a 19-Yr Review of the The Swiss National Reference Center
Details
Serval ID
serval:BIB_847E482ACD64
Type
Inproceedings: an article in a conference proceedings.
Publication sub-type
Abstract (Abstract): shot summary in a article that contain essentials elements presented during a scientific conference, lecture or from a poster.
Collection
Publications
Institution
Title
Successful Serology-Based Intervention to Increase Protection against Vaccine-Preventable Diseases in Liver Transplanted Children: a 19-Yr Review of the The Swiss National Reference Center
Title of the conference
6th Congress of the International Pediatric Transplant Association
Address
Montreal, Canada, June 25-28, 2011
ISBN
1397-3142
Publication state
Published
Issued date
2011
Volume
15
Series
Pediatric Transplantation
Pages
95
Language
english
Notes
Meeting Abstract: 219
Abstract
PURPOSE: Since children referred for orthotopic liver transplantation (OLT) in Switzerland were not vaccinated optimally, new guidelines were set up and recommended to base catch-up immunization on serum antibody titers against vaccinepreventable diseases, before and after OLT.
METHOD: We measure the results of this serology-based intervention by comparing vaccine coverage and antibody titers in the pre- (1990-2002, P1) and post-intervention (2003-2008, P2) cohorts. Antibodies are measured by ELISA.
RESULTS: 44 P1 and 30 P2 children were evaluated. At pre-OLT visit, diphtheria (D), tetanus (T), S. pneumoniae (SPn) and measles-mumps-rubella (MMR) serologies were checked more frequently in P2 than P1 (P<0.05). More P2 children were up-todate for diphtheria-tetanus-pertussis (DTaP) and MMR (P<0.05) or had received ≥1 dose of hepatitis B (HBV), hepatitis A (HAV), SPn and varicella-zoster virus (VZV) vaccines (P<0.05). One year post-OLT, DT, SPn, MMR and VZV serologies were more frequently checked (P<0.05) and antibody titers were higher for DT and HAV (P<0.05) in P2. Gender, age or diagnosis didn't explain these differences. Among P2 patients, pre- and post-OLT titers for D, T, Haemophilus influenzae type b (Hib), HBV, SPn14 and SPn19 were correlated (P<0.05 for all).
CONCLUSION: Protection against vaccine-preventable diseases of high-risk children like OLT patients can be significantly improved by serology-based intervention for vaccine-preventable diseases
METHOD: We measure the results of this serology-based intervention by comparing vaccine coverage and antibody titers in the pre- (1990-2002, P1) and post-intervention (2003-2008, P2) cohorts. Antibodies are measured by ELISA.
RESULTS: 44 P1 and 30 P2 children were evaluated. At pre-OLT visit, diphtheria (D), tetanus (T), S. pneumoniae (SPn) and measles-mumps-rubella (MMR) serologies were checked more frequently in P2 than P1 (P<0.05). More P2 children were up-todate for diphtheria-tetanus-pertussis (DTaP) and MMR (P<0.05) or had received ≥1 dose of hepatitis B (HBV), hepatitis A (HAV), SPn and varicella-zoster virus (VZV) vaccines (P<0.05). One year post-OLT, DT, SPn, MMR and VZV serologies were more frequently checked (P<0.05) and antibody titers were higher for DT and HAV (P<0.05) in P2. Gender, age or diagnosis didn't explain these differences. Among P2 patients, pre- and post-OLT titers for D, T, Haemophilus influenzae type b (Hib), HBV, SPn14 and SPn19 were correlated (P<0.05 for all).
CONCLUSION: Protection against vaccine-preventable diseases of high-risk children like OLT patients can be significantly improved by serology-based intervention for vaccine-preventable diseases
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Create date
21/02/2015 11:44
Last modification date
20/08/2019 14:44
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