Article: article from journal or magazin.
CD93 is required for maintenance of antibody secretion and persistence of plasma cells in the bone marrow niche.
Proceedings of the National Academy of Sciences of the United States of America
Plasma cells represent the end stage of B-cell development and play a key role in providing an efficient antibody response, but they are also involved in numerous pathologies. Here we show that CD93, a receptor expressed during early B-cell development, is reinduced during plasma-cell differentiation. High CD93/CD138 expression was restricted to antibody-secreting cells both in T-dependent and T-independent responses as naive, memory, and germinal-center B cells remained CD93-negative. CD93 was expressed on (pre)plasmablasts/plasma cells, including long-lived plasma cells that showed decreased cell cycle activity, high levels of isotype-switched Ig secretion, and modification of the transcriptional network. T-independent and T-dependent stimuli led to re-expression of CD93 via 2 pathways, either before or after CD138 or Blimp-1 expression. Strikingly, while humoral immune responses initially proceeded normally, CD93-deficient mice were unable to maintain antibody secretion and bone-marrow plasma-cell numbers, demonstrating that CD93 is important for the maintenance of plasma cells in bone marrow niches.
Animals, Antibody Formation/immunology, Bone Marrow/immunology, Cell Differentiation, Chickens, Immunization, Mammary Tumor Virus, Mouse/immunology, Membrane Glycoproteins/immunology, Mice, Plasma Cells/cytology, Plasma Cells/immunology, Receptors, Complement/immunology, Retroviridae Infections/immunology, Syndecan-1/immunology, T-Lymphocytes/immunology, Trans-Activators/immunology, Transcription Factors/immunology, gamma-Globulins/immunology
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