Effect of sodium intake on gene expression and plasma levels of ANF in rats.

Détails

ID Serval
serval:BIB_8475B1ED66B9
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Effect of sodium intake on gene expression and plasma levels of ANF in rats.
Périodique
American Journal of Physiology. Heart and Circulatory Physiology
Auteur(s)
Lattion A.L., Aubert J.F., Flückiger J.P., Nussberger J., Waeber B., Brunner H.R.
ISSN
0363-6135
ISSN-L
0363-6135
Statut éditorial
Publié
Date de publication
1988
Volume
255
Numéro
2 Pt 2
Pages
H245-H249
Langue
anglais
Notes
Journal Article Research Support, Non-U.S. Gov't --- Old month value: Aug
Résumé
The effect of short- and long-term sodium loading and sodium restriction on the gene expression as well as on circulating plasma levels of atrial natriuretic factor (ANF) was evaluated in normotensive Wistar rats. These rats were fed either a low-, a regular-, or a high-sodium diet (regular diet and 1% saline as drinking fluid) and studied after 1 and 3 wk. The ANF mRNA was determined in pooled atria and ventricles of the different groups of rats, using the dot-blot technique. Plasma ANF levels were measured with a radioimmunoassay. After 1 wk on the high-sodium diet, ANF mRNA was increased in right atria and ventricles together with circulating ANF levels when compared with animals maintained for the same period on a low-sodium diet. After 3 wk on the various diets, the differences in cardiac ANF mRNA and in plasma ANF levels had disappeared. Gene expression of ANF was also looked for in different areas of the brain, lung, thyroid, adrenals, and the kidney; no hybridization was detected in any of these organs. These data suggest that in rats, the transcription of the ANF gene and peptide release in enhanced only during short-term adaptation to dietary sodium loading.
Mots-clé
Animals, Atrial Function, Atrial Natriuretic Factor, Blood Pressure, Body Weight, Heart, Male, Myocardium, Organ Size, Organ Specificity, RNA, Messenger, Radioimmunoassay, Rats, Rats, Inbred Strains, Reference Values, Sodium, Dietary, Transcription, Genetic, Ventricular Function
Pubmed
Web of science
Création de la notice
05/03/2008 17:39
Dernière modification de la notice
03/03/2018 18:55
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