Management of patients with uveal metastases at the Liverpool Ocular Oncology Centre.

Détails

ID Serval
serval:BIB_84604BC19D0C
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Management of patients with uveal metastases at the Liverpool Ocular Oncology Centre.
Périodique
British Journal of Ophthalmology
Auteur(s)
Konstantinidis L., Rospond-Kubiak I., Zeolite I., Heimann H., Groenewald C., Coupland S.E., Damato B.
ISSN
1468-2079 (Electronic)
ISSN-L
0007-1161
Statut éditorial
Publié
Date de publication
2014
Peer-reviewed
Oui
Volume
98
Numéro
1
Pages
92-98
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish
Résumé
BACKGROUND: Uveal metastasis is the most common intraocular malignancy.
METHODS: This was a retrospective study of all patients with uveal metastases referred to the Liverpool Ocular Oncology Centre between January 2007 and December 2012. Biopsy was performed as a primary investigation if the clinical examination suggested metastasis with no evidence of any extraocular metastases.
RESULTS: Ninety-six patients (109 eyes) were included. Breast and lung carcinomas were the most common primary malignancies, affecting 41 and 27 patients, respectively. The median time interval between detection of primary cancer and uveal metastasis was 24 months (range 1-288 months). Thirty-nine patients underwent ocular biopsy, confirming the diagnosis in all patients. The biopsy indicated the site of origin in 24 out of the 27 without a known primary tumour. In 7 of these 27 cases, previous systemic investigations had failed to identify the primary tumour. Seventy-three patients received external beam irradiation; two patients received photodynamic therapy; and two patients had Ru-106 plaque radiotherapy. The visual acuity was stable or improved in 75.5% of the cases.
CONCLUSIONS: Immediate biopsy provides a quick diagnosis that may expedite treatment and improve any opportunities for conserving vision while facilitating the general oncologic management on these patients.
Mots-clé
Adult, Aged, Aged, 80 and over, Antineoplastic Agents/therapeutic use, Biopsy, Breast Neoplasms/pathology, Carcinoma/diagnosis, Carcinoma/secondary, Chemotherapy, Adjuvant, Early Diagnosis, Female, Humans, Lung Neoplasms/pathology, Male, Middle Aged, Photochemotherapy, Retrospective Studies, Uveal Neoplasms/diagnosis, Uveal Neoplasms/secondary, Young Adult
Pubmed
Web of science
Création de la notice
06/02/2015 10:42
Dernière modification de la notice
03/03/2018 18:54
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