Effect of multiple oral doses of androgenic anabolic steroids on endurance performance and serum indices of physical stress in healthy male subjects.

Détails

ID Serval
serval:BIB_845A543BA783
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Effect of multiple oral doses of androgenic anabolic steroids on endurance performance and serum indices of physical stress in healthy male subjects.
Périodique
European journal of applied physiology
Auteur(s)
Baume N., Schumacher Y.O., Sottas P.E., Bagutti C., Cauderay M., Mangin P., Saugy M.
ISSN
1439-6319
Statut éditorial
Publié
Date de publication
2006
Peer-reviewed
Oui
Volume
98
Numéro
4
Pages
329-40
Langue
anglais
Notes
Publication types: Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't - Publication Status: ppublish
Résumé
Anabolic androgenic steroids (AAS) are doping agents that are mostly used for improvement of strength and muscle hypertrophy. In some sports, athletes reported that the intake of AAS is associated with a better recovery, a higher training load capacity and therefore an increase in physical and mental performances. The purpose of this study was to evaluate, the effect of multiple doses of AAS on different physiological parameters that could indirectly relate the physical state of athletes during a hard endurance training program. In a double blind settings, three groups (n = 9, 8 and 8) were orally administered placebo, testosterone undecanoate or 19-norandrostenedione, 12 times during 1 month. Serum biomarkers (creatine kinase, ASAT and urea), serum hormone profiles (testosterone, cortisol and LH) and urinary catecholamines (noradrenalin, adrenalin and dopamine) were evaluated during the treatment. Running performance was assessed before and after the intervention phase by means of a standardized treadmill test. None of the measured biochemical variables showed significant impact of AAS on physical stress level. Data from exercise testing on submaximal and maximal level did not reveal any performance differences between the three groups or their response to the treatment. In the present study, no effect of multiple oral doses of AAS on endurance performance or bioserum recovery markers was found.
Mots-clé
Adult, Anabolic Agents, Androgens, Androstenedione, Biological Markers, Catecholamines, Double-Blind Method, Exercise Test, Heart Rate, Hormones, Humans, Hydrocortisone, Lactic Acid, Male, Physical Endurance, Physical Fitness, Running, Steroids, Stress, Psychological, Testosterone
Pubmed
Web of science
Création de la notice
16/05/2008 17:25
Dernière modification de la notice
03/03/2018 18:54
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