The role of migration and domestic transmission in the spread of HIV-1 non-B subtypes in Switzerland.

Détails

ID Serval
serval:BIB_84330699B06F
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
The role of migration and domestic transmission in the spread of HIV-1 non-B subtypes in Switzerland.
Périodique
Journal of Infectious Diseases
Auteur(s)
von Wyl V., Kouyos R.D., Yerly S., Böni J., Shah C., Bürgisser P., Klimkait T., Weber R., Hirschel B., Cavassini M., Staehelin C., Battegay M., Vernazza P.L., Bernasconi E., Ledergerber B., Bonhoeffer S., Günthard H.F.
Collaborateur(s)
Swiss HIV Cohort Study
Contributeur(s)
Barth J., Battegay M., Bernasconi E., Böni J., Bucher H., Bu P., Burton-Jeangros C., Calmy A., Cavassini M., Dubs R., Egger M., Elzi L., Fehr J., Fischer M., Flepp M., Francioli P., Furrer H., Fux C., Gorgievski M., Günthard H., Hasse B., Hirsch H., Hirschel B., Ho I., Kahlert C., Kaiser L., Keiser O., Kind C., Klimkait T., Kovari H., Ledergerber B., Martinetti G., Martinez de Tejada B., Müller N., Nadal D., Pantaleo G., Rauch A., Regenass S., Rickenbach M., Rudin C., Schmid P., Schultze D., Schöni-Affolter F., Schüpbach J., Speck R., Taffé P., Telenti A., Trkola A., Vernazza P., von Wyl V., Weber R., Yerly S.
ISSN
1537-6613 (Electronic)
ISSN-L
0022-1899
Statut éditorial
Publié
Date de publication
2011
Volume
204
Numéro
7
Pages
1095-1103
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
BACKGROUND: By analyzing human immunodeficiency virus type 1 (HIV-1) pol sequences from the Swiss HIV Cohort Study (SHCS), we explored whether the prevalence of non-B subtypes reflects domestic transmission or migration patterns.
METHODS: Swiss non-B sequences and sequences collected abroad were pooled to construct maximum likelihood trees, which were analyzed for Swiss-specific subepidemics, (subtrees including ≥80% Swiss sequences, bootstrap >70%; macroscale analysis) or evidence for domestic transmission (sequence pairs with genetic distance <1.5%, bootstrap ≥98%; microscale analysis).
RESULTS: Of 8287 SHCS participants, 1732 (21%) were infected with non-B subtypes, of which A (n = 328), C (n = 272), CRF01_AE (n = 258), and CRF02_AG (n = 285) were studied further. The macroscale analysis revealed that 21% (A), 16% (C), 24% (CRF01_AE), and 28% (CRF02_AG) belonged to Swiss-specific subepidemics. The microscale analysis identified 26 possible transmission pairs: 3 (12%) including only homosexual Swiss men of white ethnicity; 3 (12%) including homosexual white men from Switzerland and partners from foreign countries; and 10 (38%) involving heterosexual white Swiss men and females of different nationality and predominantly nonwhite ethnicity.
CONCLUSIONS: Of all non-B infections diagnosed in Switzerland, <25% could be prevented by domestic interventions. Awareness should be raised among immigrants and Swiss individuals with partners from high prevalence countries to contain the spread of non-B subtypes.
Mots-clé
African Continental Ancestry Group/statistics & numerical data, Asian Continental Ancestry Group/statistics & numerical data, Cluster Analysis, Emigration and Immigration, European Continental Ancestry Group/statistics & numerical data, Female, Gene Products, pol/metabolism, HIV Infections/ethnology, HIV Infections/genetics, HIV-1/genetics, HIV-1/metabolism, Heterosexuality/statistics & numerical data, Homosexuality, Male/statistics & numerical data, Humans, Likelihood Functions, Logistic Models, Male, Molecular Sequence Data, Prevalence, Switzerland/epidemiology
Pubmed
Web of science
Open Access
Oui
Création de la notice
29/09/2011 9:47
Dernière modification de la notice
08/05/2019 21:19
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