Cis association of Ly49A with MHC class I restricts natural killer cell inhibition.

Détails

ID Serval
serval:BIB_84274940A2AD
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Cis association of Ly49A with MHC class I restricts natural killer cell inhibition.
Périodique
Nature Immunology
Auteur(s)
Doucey M.A., Scarpellino L., Zimmer J., Guillaume P., Luescher I.F., Bron C., Held W.
ISSN
1529-2908[print], 1529-2908[linking]
Statut éditorial
Publié
Date de publication
2004
Peer-reviewed
Oui
Volume
5
Numéro
3
Pages
328-336
Langue
anglais
Résumé
Natural killer (NK) cell function is negatively regulated by inhibitory receptors interacting with major histocompatibility complex class I molecules expressed on target cells. Here we show that the inhibitory Ly49A NK cell receptor not only binds to its H-2D(d) ligand expressed on potential target cells (in trans) but also is constitutively associated with H-2D(d) in cis (on the same cell). Cis association and trans interaction occur through the same binding site. Consequently, cis association restricts the number of Ly49A receptors available for binding of H-2D(d) on target cells and reduces NK cell inhibition through Ly49A. By lowering the threshold at which NK cell activation exceeds NK cell inhibition, cis interaction allows optimal discrimination of normal and abnormal host cells.
Mots-clé
Animals, Antigens, Ly/genetics, Antigens, Ly/metabolism, Binding Sites, Cell Line, Cell Line, Tumor, Cytotoxicity Tests, Immunologic, Cytotoxicity, Immunologic, H-2 Antigens/metabolism, Histocompatibility Antigens Class I/metabolism, Killer Cells, Natural/immunology, Lectins, C-Type, Mice, Mice, Inbred C57BL, Mice, Transgenic, Models, Immunological, Mosaicism, NK Cell Lectin-Like Receptor Subfamily A, Neoplasms/immunology, Receptors, Immunologic/metabolism, Receptors, Immunologic/physiology, Receptors, NK Cell Lectin-Like, Transfection
Pubmed
Web of science
Création de la notice
28/01/2008 12:20
Dernière modification de la notice
03/03/2018 18:54
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