Impaired insulin-induced sympathetic neural activation and vasodilation in skeletal muscle in obese humans

Détails

ID Serval
serval:BIB_84273E0C4B3A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Impaired insulin-induced sympathetic neural activation and vasodilation in skeletal muscle in obese humans
Périodique
Journal of Clinical Investigation
Auteur(s)
Vollenweider  P., Randin  D., Tappy  L., Jequier  E., Nicod  P., Scherrer  U.
ISSN
0021-9738 (Print)
Statut éditorial
Publié
Date de publication
06/1994
Volume
93
Numéro
6
Pages
2365-71
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jun
Résumé
The sympathetic nervous system is an important regulatory mechanism of both metabolic and cardiovascular function, and altered sympathetic activity may play a role in the etiology and/or complications of obesity. In lean subjects, insulin evokes sympathetic activation and vasodilation in skeletal muscle. In obese subjects such vasodilation is impaired and, in turn, may contribute to insulin resistance. To examine the relationship between sympathetic and vasodilatory responses in skeletal muscle to hyperinsulinemia, we simultaneously measured muscle sympathetic nerve activity (MSNA) and calf blood flow at basal and during a 2-h hyperinsulinemic (6 pmol/kg per min) euglycemic clamp in eight lean and eight obese subjects. The major findings of this study are twofold: obese subjects had a 2.2 times higher fasting rate of MSNA, and euglycemic hyperinsulinemia, which more than doubled MSNA and increased calf blood flow by roughly 30% in lean subjects, had only a minor vasodilatory and sympathoexcitatory effect in obese subjects. In contrast, two non-insulin-sympathetic stimuli evoked comparably large increases in MSNA in lean and obese subjects. We conclude that insulin resistance in obese subjects is associated with increased fasting MSNA and a specific impairment of sympathetic neural responsiveness to physiological hyperinsulinemia in skeletal muscle tissue.
Mots-clé
Adult Blood Glucose/analysis Female Humans Insulin/blood/*pharmacology Male Muscles/blood supply/*innervation Obesity/*physiopathology Regional Blood Flow/drug effects Sympathetic Nervous System/*drug effects/physiology Vascular Resistance/drug effects Vasodilation/*drug effects
Pubmed
Web of science
Création de la notice
24/01/2008 14:36
Dernière modification de la notice
03/03/2018 18:54
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