Characterization of normal brain-reactive antibodies in glioma cyst fluids

Détails

ID Serval
serval:BIB_842739C68EF2
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Characterization of normal brain-reactive antibodies in glioma cyst fluids
Périodique
Journal of Neuroimmunology
Auteur(s)
Brunet  J. M., Berger  F., Gustin  T., Laine  M., Benabid  A. L.
ISSN
0165-5728
Statut éditorial
Publié
Date de publication
08/1993
Peer-reviewed
Oui
Volume
47
Numéro
1
Pages
63-72
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Aug
Résumé
Anti-normal brain antibodies were studied in glioma cyst fluids. Cyst fluids were obtained by stereotaxic puncture from 34 patients with cystic gliomas. Immunoglobulins were analyzed by immunohistochemistry, immuno-Western blotting, concentration measures, and isoelectrofocalization. 80% of cyst fluids stained astrocytes and/or microvessels in non-tumoral white matter. In white matter extracts, cyst fluids recognized five immunoreactive bands having apparent molecular masses of 50-75 kDa. Although cyst proteins could be of systemic origin, isoelectrofocalization analysis suggests an additional local immune response. These antibody activities could be involved in certain peritumoral events such as brain edema.
Mots-clé
Autoantibodies/*analysis Blotting, Western Body Fluids/*immunology Brain/*immunology Brain Neoplasms/*immunology Cysts/*immunology Electrophoresis, Gel, Two-Dimensional Glioma/*immunology Humans Immunodiffusion Immunoenzyme Techniques Isoelectric Focusing
Pubmed
Web of science
Création de la notice
06/02/2008 10:44
Dernière modification de la notice
03/03/2018 18:54
Données d'usage