Connexins, diabetes and the metabolic syndrome.

Détails

ID Serval
serval:BIB_83E658358E61
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Connexins, diabetes and the metabolic syndrome.
Périodique
Current Protein & Peptide Science
Auteur(s)
Hamelin R., Allagnat F., Haefliger J.A., Meda P.
ISSN
1389-2037
Statut éditorial
Publié
Date de publication
2009
Peer-reviewed
Oui
Volume
10
Numéro
1
Pages
18-29
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Résumé
Diabetes and the related metabolic syndrome are multi system disorders that result from improper interactions between various cell types. Even though the underlying mechanism remains to be fully understood, it is most likely that both the long and the short distance range cell interactions, which normally ensure the physiologic functioning of the pancreas, and its relationships with the insulin-targeted organs, are altered. This review focuses on the short-range type of interactions that depend on the contact between adjacent cells and, specifically, on the interactions that are dependent on connexins. The widespread distribution of these membrane proteins, their multiple modes of action, and their interactions with conditions/molecules associated to both the pathogenesis and the treatment of the 2 main forms of diabetes and the metabolic syndrome, make connexins an essential part of the chain of events that leads to metabolic diseases. Here, we review the present state of knowledge about the molecular and cell biology of the connexin genes and proteins, their general mechanisms of action, the roles specific connexin species play in the endocrine pancreas and the major insulin-targeted organs, under physiological and patho-physiological conditions.
Mots-clé
Animals, Cell Communication, Connexins/analysis, Connexins/genetics, Diabetes Mellitus/metabolism, Diabetes Mellitus/physiopathology, Humans, Metabolic Syndrome X/metabolism, Metabolic Syndrome X/physiopathology, Pancreas/metabolism
Pubmed
Web of science
Création de la notice
27/01/2010 15:22
Dernière modification de la notice
10/05/2019 10:35
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