Connexins, diabetes and the metabolic syndrome.

Details

Serval ID
serval:BIB_83E658358E61
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Connexins, diabetes and the metabolic syndrome.
Journal
Current Protein & Peptide Science
Author(s)
Hamelin R., Allagnat F., Haefliger J.A., Meda P.
ISSN
1389-2037
Publication state
Published
Issued date
2009
Peer-reviewed
Oui
Volume
10
Number
1
Pages
18-29
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Abstract
Diabetes and the related metabolic syndrome are multi system disorders that result from improper interactions between various cell types. Even though the underlying mechanism remains to be fully understood, it is most likely that both the long and the short distance range cell interactions, which normally ensure the physiologic functioning of the pancreas, and its relationships with the insulin-targeted organs, are altered. This review focuses on the short-range type of interactions that depend on the contact between adjacent cells and, specifically, on the interactions that are dependent on connexins. The widespread distribution of these membrane proteins, their multiple modes of action, and their interactions with conditions/molecules associated to both the pathogenesis and the treatment of the 2 main forms of diabetes and the metabolic syndrome, make connexins an essential part of the chain of events that leads to metabolic diseases. Here, we review the present state of knowledge about the molecular and cell biology of the connexin genes and proteins, their general mechanisms of action, the roles specific connexin species play in the endocrine pancreas and the major insulin-targeted organs, under physiological and patho-physiological conditions.
Keywords
Animals, Cell Communication, Connexins/analysis, Connexins/genetics, Diabetes Mellitus/metabolism, Diabetes Mellitus/physiopathology, Humans, Metabolic Syndrome X/metabolism, Metabolic Syndrome X/physiopathology, Pancreas/metabolism
Pubmed
Web of science
Create date
27/01/2010 14:22
Last modification date
20/08/2019 14:43
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