Hepatic nonoxidative disposal of an oral glucose meal in patients with liver cirrhosis
Details
Serval ID
serval:BIB_83CD31387D4C
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Hepatic nonoxidative disposal of an oral glucose meal in patients with liver cirrhosis
Journal
Metabolism: Clinical and Experimental
ISSN
0026-0495 (Print)
Publication state
Published
Issued date
10/1999
Volume
48
Number
10
Pages
1260-6
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Oct
Research Support, Non-U.S. Gov't --- Old month value: Oct
Abstract
Seven patients with liver cirrhosis and five healthy subjects were studied over 4 hours after ingestion of a glucose meal to determine whether alterations of hepatic nonoxidative glucose disposal participate in the pathogenesis of impaired glucose tolerance. Hepatic uridyl-diphosphoglucose (UDPG) turnover was calculated from the isotopic enrichment of urinary acetaminophen glucuronide during continuous infusion of 13C-galactose and used as an index of hepatic glycogen synthesis. Patients with cirrhosis had postprandial hyperglycemia and decreased glucose clearance, but hepatic UDPG turnover was not altered (1.84 +/- 0.29 mg/kg fat-free mass min v 1.76 +/- 0.15 in controls, nonsignificant). It is concluded that hepatic postprandial glycogen synthesis is unaltered in patients with advanced cirrhosis, demonstrating important hepatic functional reserve.
Keywords
Adult
Carbon Isotopes
Eating
Female
Galactose/metabolism
Glucose/*metabolism
Glucose Intolerance/etiology/physiopathology
Humans
Hyperglycemia/etiology/metabolism
Intestinal Absorption
Liver/*metabolism
Liver Cirrhosis/etiology/*metabolism
Liver Glycogen/biosynthesis
Male
Middle Aged
Postprandial Period
Prothrombin Time
Reference Values
Uridine Diphosphate Glucose/metabolism
Pubmed
Web of science
Create date
24/01/2008 14:36
Last modification date
20/08/2019 15:43