Reshaping the remodelled left ventricle: a new concept.

Détails

ID Serval
serval:BIB_83BC231323E0
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Reshaping the remodelled left ventricle: a new concept.
Périodique
European Journal of Cardio-Thoracic Surgery
Auteur(s)
Mueller X.M., Tevaearai H.T., Tucker O., Boone Y., von Segesser L.K.
ISSN
1010-7940
Statut éditorial
Publié
Date de publication
2001
Peer-reviewed
Oui
Volume
20
Numéro
4
Pages
786-791
Langue
anglais
Résumé
OBJECTIVE: Based on the law of Laplace, transventricular tension members were designed to diminish wall stress by changing the left ventricle (LV) globular shape to a bilobular one, thus reducing the ventricular wall radius of curvature. This concept was tested in a model of congestive heart failure. METHODS: Seven calves were used for the study (74.3+/-4.2 kg). Treatment efficacy was assessed with sonomicrometric wall motion analysis coupled with intraventricular pressure measurement. Preload increase was applied stepwise with tension members in released and tightened position. RESULTS: Tightening of the tension members improved systolic function for CVP>10 mmHg (dP/dt: 828+/-122 vs. 895+/-112 mmHg/s, P=0.019, for baseline and 20% stress level reduction respectively; wall thickening: 11.6+/-1.5 vs. 13.3+/-1.7%, P<0.001) and diastolic function (LV end-diastolic pressure: 15.9+/-4.8 vs. 13.6+/-2.7 mmHg, P<0.001, for CVP>10 mmHg; peak rate of wall thinning: -12.2+/-2.2 vs. -14+/-2.3 cm(2)/s, P<0.001 and logistic time constant of isovolumic relaxation: 48.4 +/-10.9 vs. 39.8+/-9.6ms, P<0.001, for CVP>5 mmHg). CONCLUSIONS: This less aggressive LV reduction method significantly improves contractility and relaxation parameters in this model of congestive heart failure.
Mots-clé
Animals, Cardiac Volume, Cattle, Heart Failure, Heart Ventricles, Hemodynamics, Myocardial Contraction, Systole, Ventricular Remodeling
Pubmed
Web of science
Open Access
Oui
Création de la notice
14/02/2008 15:19
Dernière modification de la notice
08/05/2019 21:17
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