Psychotherapeutic interventions are a cornerstone of modern palliative care. In this context, they are as diverse as psychotherapeutic approaches in general and encompass modalities from the psychoanalytic, cognitive behavioral, systemic, and existential traditions. All of these psychotherapies are based on inherent and often implicit values and are closely interrelated with philosophical traditions. In psychological practice in palliative care, professionals encounter a wide range of ethical questions that can be classified according to the four principles of biomedical ethics: beneficence, non-maleficence, respect for autonomy, and justice. This chapter highlights some of the most salient of these ethical questions to help the reader become aware and reflect on them.