The hypocretins and the reward function: what have we learned so far?

Détails

Ressource 1Télécharger: BIB_83A3D35B8822.P001.pdf (1268.84 [Ko])
Etat: Serval
Version: Final published version
ID Serval
serval:BIB_83A3D35B8822
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
The hypocretins and the reward function: what have we learned so far?
Périodique
Frontiers In Behavioral Neuroscience
Auteur(s)
Boutrel B., Steiner N., Halfon O.
ISSN
1662-5153 (Electronic)
ISSN-L
1662-5153
Statut éditorial
Publié
Date de publication
2013
Peer-reviewed
Oui
Volume
7
Pages
59
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: epublishPDF : REVIEW ARTICLE
Résumé
A general consensus acknowledges that drug consumption (including alcohol, tobacco, and illicit drugs) constitutes the leading cause of preventable death worldwide. But the global burden of drug abuse extends the mortality statistics. Indeed, the comorbid long-term debilitating effects of the disease also significantly deteriorate the quality of life of individuals suffering from addiction disorders. Despite the large body of evidence delineating the cellular and molecular adaptations induced by chronic drug consumption, the brain mechanisms responsible for drug craving and relapse remain insufficiently understood, and even the most recent developments in the field have not brought significant improvement in the management of drug dependence. Though, recent preclinical evidence suggests that disrupting the hypocretin (orexin) system may serve as an anticraving medication therapy. Here, we discuss how the hypocretins, which orchestrate normal wakefulness, metabolic health and the execution of goal-oriented behaviors, may be compromised and contribute to elicit compulsive drug seeking. We propose an overview on the most recent studies demonstrating an important role for the hypocretin neuropeptide system in the regulation of drug reward and the prevention of drug relapse, and we question the relevance of disrupting the hypocretin system to alleviate symptoms of drug addiction.
Pubmed
Web of science
Open Access
Oui
Création de la notice
21/06/2013 11:58
Dernière modification de la notice
08/05/2019 21:17
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