Blood and brain magnesium in inbred mice and their correlation with sleep quality.

Détails

ID Serval
serval:BIB_835F67417F01
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Blood and brain magnesium in inbred mice and their correlation with sleep quality.
Périodique
American journal of physiology. Regulatory, integrative and comparative physiology
Auteur(s)
Chollet D., Franken P., Raffin Y., Malafosse A., Widmer J., Tafti M.
ISSN
0363-6119
Statut éditorial
Publié
Date de publication
2000
Peer-reviewed
Oui
Volume
279
Numéro
6
Pages
R2173-R2178
Langue
anglais
Résumé
A strong genetic component in the regulation of blood magnesium (Mg) levels has been demonstrated. The regulation and distribution of brain Mg levels, however, have never been assessed. Herein we report on the genetic variation of peripheral and central Mg levels in six inbred strains of mice. In addition, the possible involvement of Mg in sleep regulation was assessed by establishing correlations between Mg and sleep parameters obtained before and after a 6-h sleep deprivation. Although genotype strongly determined blood Mg levels, it did not affect brain Mg, suggesting that central and peripheral Mg are regulated differently. Central Mg displayed a highly structure-specific distribution with frontal cortex having the highest and brain stem the lowest values. Whereas for the amount and distribution of baseline sleep only marginal correlations with Mg were found, Mg contents in four of nine brain structures were highly positively correlated with the length of slow-wave sleep episodes during recovery. This relationship suggests that higher levels of Mg in specific brain sites promote sleep quality as part of a recovery process.
Mots-clé
Animals, Brain, Magnesium, Mice, Mice, Inbred AKR, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Inbred DBA, Mice, Inbred Strains, Organ Specificity, Sleep, Species Specificity
Pubmed
Web of science
Création de la notice
24/01/2008 16:55
Dernière modification de la notice
20/08/2019 15:43
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