C3 glomerulopathy: a new classification

Details

Serval ID
serval:BIB_82C5C0C13E04
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
C3 glomerulopathy: a new classification
Journal
Nat Rev Nephrol
Author(s)
Fakhouri F., Fremeaux-Bacchi V., Noel L. H., Cook H. T., Pickering M. C.
ISSN
1759-507X (Electronic)
ISSN-L
1759-5061
Publication state
Published
Issued date
08/2010
Volume
6
Number
8
Pages
494-9
Language
english
Notes
Fakhouri, Fadi
Fremeaux-Bacchi, Veronique
Noel, Laure-Helene
Cook, H Terence
Pickering, Matthew C
eng
Review
England
Nat Rev Nephrol. 2010 Aug;6(8):494-9. doi: 10.1038/nrneph.2010.85. Epub 2010 Jul 6.
Abstract
Several distinct pathological patterns of glomerular inflammation are associated with abnormal regulation of the complement system, specifically, with dysregulation of the alternative pathway of the complement system. However, these conditions share the pathological finding of complement C3 (C3) deposited within the glomerulus in the absence of substantial immunoglobulin. This finding has alerted us and others to the possible presence of genetic and acquired complement dysregulation in individual patients. This article summarizes our current understanding of the relationship between dysregulation of the complement system and glomerular inflammation. Here, we suggest that glomerular pathologies that are characterized by the isolated deposition of C3 could usefully be classified by the term C3 glomerulopathy. In our view, this classification would alert the pathologist and nephrologist to the importance of screening for acquired and genetic abnormalities in complement regulation. In the future, it could help to identify individuals who might benefit from therapeutic inhibition of the complement system.
Keywords
Complement C3/*metabolism, Glomerulonephritis/*classification/etiology, Humans, Kidney Glomerulus/metabolism/pathology, Risk Factors
Pubmed
Create date
01/03/2022 10:18
Last modification date
02/03/2022 6:36
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