T-cell fate and function: PKC-theta and beyond.

Détails

ID Serval
serval:BIB_82B578953B1D
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
T-cell fate and function: PKC-theta and beyond.
Périodique
Trends in Immunology
Auteur(s)
Marsland B.J., Kopf M.
ISSN
1471-4906
Statut éditorial
Publié
Date de publication
2008
Peer-reviewed
Oui
Volume
29
Numéro
4
Pages
179-185
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Résumé
The serine/threonine-specific protein kinase C-theta (PKC-theta) is a core component of the immunological synapse that was shown in vitro to play a central role in the activation of T cells after T cell receptor (TCR) and co-stimulatory molecule engagement. In recent years, a series of in vivo studies have shown that the situation is far more complex; specifically, PKC-theta signaling is differentially required for Th1, Th2, Th17 and CD8+ cytotoxic T-cell responses. These studies highlight the combination of signals that directly regulate T-cell differentiation and effector responses. In this review, we highlight recent in vivo studies investigating PKC-theta function and discuss this in the context of how the integration of extrinsic signals determines T cell fate and function.
Mots-clé
Animals, Antigen-Presenting Cells/immunology, Antigen-Presenting Cells/metabolism, CD4-Positive T-Lymphocytes/cytology, CD4-Positive T-Lymphocytes/immunology, CD8-Positive T-Lymphocytes/immunology, CD8-Positive T-Lymphocytes/metabolism, Cell Differentiation, Cell Proliferation, Cytokines/immunology, Cytokines/metabolism, Gap Junctions/enzymology, Gap Junctions/immunology, Lymphocyte Activation, Protein Kinase C/metabolism, Receptors, Antigen, T-Cell/immunology, Receptors, Antigen, T-Cell/metabolism, Signal Transduction, T-Lymphocytes, Regulatory/immunology, T-Lymphocytes, Regulatory/metabolism, Th1 Cells/immunology, Th1 Cells/metabolism, Th2 Cells/immunology, Th2 Cells/metabolism
Pubmed
Web of science
Création de la notice
18/01/2010 14:04
Dernière modification de la notice
03/03/2018 18:51
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