Article: article from journal or magazin.
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
T-cell fate and function: PKC-theta and beyond.
Trends in Immunology
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
The serine/threonine-specific protein kinase C-theta (PKC-theta) is a core component of the immunological synapse that was shown in vitro to play a central role in the activation of T cells after T cell receptor (TCR) and co-stimulatory molecule engagement. In recent years, a series of in vivo studies have shown that the situation is far more complex; specifically, PKC-theta signaling is differentially required for Th1, Th2, Th17 and CD8+ cytotoxic T-cell responses. These studies highlight the combination of signals that directly regulate T-cell differentiation and effector responses. In this review, we highlight recent in vivo studies investigating PKC-theta function and discuss this in the context of how the integration of extrinsic signals determines T cell fate and function.
Animals, Antigen-Presenting Cells/immunology, Antigen-Presenting Cells/metabolism, CD4-Positive T-Lymphocytes/cytology, CD4-Positive T-Lymphocytes/immunology, CD8-Positive T-Lymphocytes/immunology, CD8-Positive T-Lymphocytes/metabolism, Cell Differentiation, Cell Proliferation, Cytokines/immunology, Cytokines/metabolism, Gap Junctions/enzymology, Gap Junctions/immunology, Lymphocyte Activation, Protein Kinase C/metabolism, Receptors, Antigen, T-Cell/immunology, Receptors, Antigen, T-Cell/metabolism, Signal Transduction, T-Lymphocytes, Regulatory/immunology, T-Lymphocytes, Regulatory/metabolism, Th1 Cells/immunology, Th1 Cells/metabolism, Th2 Cells/immunology, Th2 Cells/metabolism
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