Fatal tolperisone poisoning: autopsy and toxicology findings in three suicide cases.

Détails

ID Serval
serval:BIB_82AB167D123F
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Fatal tolperisone poisoning: autopsy and toxicology findings in three suicide cases.
Périodique
Forensic Science International
Auteur(s)
Sporkert F., Brunel C., Augsburger M.P., Mangin P.
ISSN
1872-6283 (Electronic)
ISSN-L
0379-0738
Statut éditorial
Publié
Date de publication
2012
Volume
215
Numéro
1-3
Pages
101-104
Langue
anglais
Notes
Publication types: Journal Article
Résumé
Tolperisone (Mydocalm) is a centrally acting muscle relaxant with few sedative side effects that is used for the treatment of chronic pain conditions. We describe three cases of suicidal tolperisone poisoning in three healthy young subjects in the years 2006, 2008 and 2009. In all cases, macroscopic and microscopic autopsy findings did not reveal the cause of death. Systematic toxicological analysis (STA) including immunological tests, screening for volatile substances and blood, urine and gastric content screening by GC-MS and HPLC-DAD demonstrated the presence of tolperisone in all cases. In addition to tolperisone, only the analgesics paracetamol (acetaminophen), ibuprofen and naproxen could be detected. The blood ethanol concentrations were all lower than 0.10 g/kg. Tolperisone was extracted by liquid-liquid extraction using n-chlorobutane as the extraction solvent. The quantification was performed by GC-NPD analysis of blood, urine and gastric content. Tolperisone concentrations of 7.0 mg/l, 14 mg/l and 19 mg/l were found in the blood of the deceased. In the absence of other autopsy findings, the deaths in these three cases were finally explained as a result of lethal tolperisone ingestion. To the best of our knowledge, these three cases are the first reported cases of suicidal tolperisone poisonings.
Pubmed
Web of science
Création de la notice
01/04/2012 15:09
Dernière modification de la notice
03/03/2018 18:50
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