Surrogate markers for atherosclerosis in overweight subjects with atherogenic dyslipidemia: the GEMS project.

Details

Serval ID
serval:BIB_82A0A02C7980
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Surrogate markers for atherosclerosis in overweight subjects with atherogenic dyslipidemia: the GEMS project.
Journal
Angiology
Author(s)
Genoud M., Wietlisbach V., Feihl F., Mermod A., Morin D., Darioli R., Nicod P., Mooser V., Waeber B., Hayoz D., Waeber G.
ISSN
1940-1574
Publication state
Published
Issued date
2008
Peer-reviewed
Oui
Volume
59
Number
4
Pages
484-492
Language
english
Abstract
Metabolic syndrome is a constellation of major risk factors for cardiovascular disease. In affected individuals with this syndrome, the independent contribution of low high-density lipoprotein-cholesterol and increased triglyceride levels to the development of atherosclerosis remains to be clarified. We assessed the relationship between these 2 parameters and several surrogate markers for atherosclerosis. One hundred and twenty overweight cases, defined as having high-density lipoprotein-cholesterol (<or=25 age- and gender-specific percentile in general population) and high triglyceride values (>or=75 percentile) were compared with 120 discordant overweight controls defined on lipid values (high-density lipoprotein-cholesterol >or=50 percentile and triglycerides <or=50 percentile). Case-control pairs were matched for age and gender. Carotid and femoral arteries were examined to determine carotid intima-media thickness and the presence of atherosclerotic plaque(s). Endothelial function was assessed by laser Doppler flowmetry in the skin microvasculature. Daytime ambulatory blood pressure monitoring was performed for each subject. Cases had higher prevalence of atherosclerotic plaques (mean 1.50 +/- 0.15 vs 0.80 +/- 0.15, P < .001), increased carotid intima-media thickness (mean 0.66 +/- 0.15 vs 0.61 +/- 0.15, P < .01), and a significantly reduced temperature-induced and postischemic endothelial vasodilation compared with controls. In conclusion, low high-density lipoprotein-cholesterol and high triglycerides levels are major contributors to peripheral atherosclerosis and are associated with an increase in intima-media thickness and impaired microvascular endothelial function in overweight individuals.
Keywords
Atherosclerosis, Biological Markers, Blood Pressure, Carotid Arteries, Case-Control Studies, Cholesterol, HDL, Dyslipidemias, Endothelium, Vascular, Female, Femoral Artery, Humans, Male, Metabolic Syndrome X, Middle Aged, Odds Ratio, Overweight, Risk Assessment, Risk Factors, Skin, Triglycerides, Vasodilation
Pubmed
Web of science
Create date
17/11/2008 8:57
Last modification date
20/08/2019 14:42
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