Frailty, Cognitive Impairment, and Incident Major Neurocognitive Disorders: Results of the NuAge Cohort Study.

Details

Serval ID
serval:BIB_827976ED714A
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Frailty, Cognitive Impairment, and Incident Major Neurocognitive Disorders: Results of the NuAge Cohort Study.
Journal
Journal of Alzheimer's disease
Author(s)
Beauchet O., Matskiv J., Gaudreau P., Allali G., Vaillant-Ciszewicz A.J., Guerin O., Gros A.
ISSN
1875-8908 (Electronic)
ISSN-L
1387-2877
Publication state
Published
Issued date
2023
Peer-reviewed
Oui
Volume
94
Number
3
Pages
1079-1092
Language
english
Notes
Publication types: Observational Study ; Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Frailty is associated with an increased risk of major neurocognitive disorders (MNCD).
This study aims to compare the Fried physical model and the CARE deficit accumulation model for their association with incident major neurocognitive disorders (MNCD), and to examine how the addition of cognitive impairment to these frailty models impacts the incidence in community-dwelling older adults.
A subset of community dwellers (n = 1,259) who participated in the "Quebec Longitudinal Study on Nutrition and Successful Aging" (NuAge) were selected in this Elderly population-based observational cohort study with 3 years of follow-up. Fried and CARE frailty stratifications into robust, pre-frail and frail groups were performed using the NuAge baseline assessment. Incident MNCD (i.e., Modified Mini Mental State (3MS) score < 79/100 and Instrumental Activity Daily Living (IADL) score < 6/8) were collected each year over a 3-year follow-up period.
A greater association with incident MNCD of the CARE frail state was observed with an increased predictive value when combined with cognitive impairment in comparison to Fried's one, the highest incidences being observed using the robust state as the reference. Results with the Fried frail state were more heterogenous, with no association with the frail state alone, whereas cognitive impairment alone showed the highest significant incidence.
The association of the CARE frail state with cognitive impairment increased the predictive value of MNCD, suggesting that the CARE frailty model may be of clinical interest when screening MCND in the elderly population.
Keywords
Humans, Aged, Frailty/epidemiology, Cohort Studies, Longitudinal Studies, Frail Elderly/psychology, Cognitive Dysfunction/epidemiology, Cognitive Dysfunction/psychology, Independent Living, Geriatric Assessment/methods, Aging, Alzheimer’s disease, cognitive impairment, cohort study, community-dwellers, frailty
Pubmed
Web of science
Create date
29/06/2023 15:21
Last modification date
28/10/2023 7:10
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