Plasma levels of tumor necrosis factor in the adult respiratory distress syndrome

Détails

ID Serval
serval:BIB_8263201B9527
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Plasma levels of tumor necrosis factor in the adult respiratory distress syndrome
Périodique
American Review of Respiratory Disease
Auteur(s)
Roten  R., Markert  M., Feihl  F., Schaller  M. D., Tagan  M. C., Perret  C.
ISSN
1073-449X
0003-0805 (Print)
Statut éditorial
Publié
Date de publication
03/1991
Volume
143
Numéro
3
Pages
590-2
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Mar
Résumé
The purpose of the study was to evaluate the role of tumor necrosis factor alpha (TNF alpha) in the pathogenesis of acute lung injury in critically ill patients. An immunoradiometric assay with an upper normal limit of 9 pg/ml was used to measure plasma TNF alpha levels (pl-TNF alpha) in 34 patients with adult respiratory distress syndrome (ARDS) and in 16 patients in whom, despite the presence of risk factors, ARDS did not develop. Pl-TNF alpha was elevated in 76% of the patients with ARDS (71 +/- 104 pg/ml) and in 48% of the at-risk patients (47 +/- 73 pg/ml); the difference between the two groups was not statistically significant. In 13 patients studied serially from the onset (Day 0) to the fifth day of ARDS, the peak pl-TNF alpha occurred later than Day 0 in seven subjects. Although the highest pl-TNF alpha levels were found in septic patients, moderately elevated values were also observed in 56% of nonseptic subjects. We conclude that plasma TNF alpha level is not a marker of ARDS but rather of shock and sepsis. These results do not exclude a pathogenic role of TNF alpha in acute lung injury since this cytokine could be produced and exert its effects within the lungs. The large incidence of abnormally high could be produced and exert its effects within the lungs. The large incidence of abnormally high plasma TNF alpha levels raises important questions on the role of this toxic cytokine in other disorders occurring in critically ill patients.
Mots-clé
Adult Female Humans Infection/blood/complications Male Middle Aged Respiratory Distress Syndrome, Adult/*blood/etiology Risk Factors Tumor Necrosis Factor-alpha/*analysis
Pubmed
Web of science
Création de la notice
25/01/2008 10:38
Dernière modification de la notice
03/03/2018 18:50
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