Comparison between incremental and single-dose allergen administration in bronchial provocation tests
Details
Serval ID
serval:BIB_82048FAC45A4
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Comparison between incremental and single-dose allergen administration in bronchial provocation tests
Journal
Journal of Asthma
ISSN
0277-0903 (Print)
Publication state
Published
Issued date
1996
Volume
33
Number
3
Pages
169-78
Notes
Comparative Study
Journal Article
Journal Article
Abstract
To study the effect of different schedules of allergen administration on the early (EAR) and late allergic reaction (LAR), 15 asthmatic patients with dual response after allergen challenge were submitted to two consecutive bronchoprovocation tests (BPT). BPT1 was carried out with semilogarithmic increases of allergen doses until a FEV1 drop of 20% was recorded. BPT2 was performed 2 weeks later using the highest allergen dose that had elicited the dual reaction in BPT1. Both EAR and LAR were very similar for a given patient. As the allergen dose used in BPT2 is smaller than the cumulative allergen dose administered in BPT1, this protocol takes into account a possible influence on BPT2 of bronchial hyperreactivity induced by BPT1 performed 2 weeks before.
Keywords
Adult
Allergens/administration & dosage/*diagnostic use
Animals
Asthma/*diagnosis/physiopathology
Bronchial Hyperreactivity/physiopathology
Bronchial Provocation Tests/*methods
Cats
Dose-Response Relationship, Drug
Female
Forced Expiratory Volume
Humans
Male
Reproducibility of Results
Time Factors
Pubmed
Web of science
Create date
25/01/2008 15:13
Last modification date
20/08/2019 15:42