Trends in carbapenemase-producing Enterobacteriaceae, France, 2012 to 2014.

Détails

Ressource 1Télécharger: art22715.pdf (901.72 [Ko])
Etat: Serval
Version: Final published version
ID Serval
serval:BIB_81FEB29B2246
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Trends in carbapenemase-producing Enterobacteriaceae, France, 2012 to 2014.
Périodique
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin
Auteur(s)
Dortet L., Cuzon G., Ponties V., Nordmann P.
ISSN
1560-7917 (Electronic)
ISSN-L
1025-496X
Statut éditorial
Publié
Date de publication
09/02/2017
Peer-reviewed
Oui
Volume
22
Numéro
6
Pages
0
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
In 2014, a total of 2,976 Enterobacteriaceae isolates with decreased susceptibility to carbapenems were received at the French Associated National Reference Center for Antibiotic Resistance (NRC) and were characterised for their molecular resistance mechanism to carbapenems and compared with results obtained during 2012 and 2013.The overall number of enterobacterial isolates with decreased susceptibility to carbapenems received at the NRC rapidly increased (more than twofold in two years) with a growing proportion of carbapenemase producers (23.1% in 2012 vs 28.6% in 2013 vs 36.2% in 2014). Between 2012 and 2014, the main carbapenemase type was OXA-48, with an increase in OXA-48 variants (mostly OXA-181) and NDM producers, whereas the number KPC producers decreased. We identified a potential spread of OXA-181 producers in the tropical region of Africa. Finally, OXA-48 and OXA-48-related enzymes remained the predominant carbapenemases in France. The number of carbapenemase-producing Escherischia coli isolates was multiplied by fivefold between 2012 and 2014, suggesting a possible dissemination in the community.

Mots-clé
Anti-Bacterial Agents/pharmacology, Bacterial Proteins/genetics, Bacterial Proteins/isolation & purification, Bacterial Proteins/secretion, Carbapenems/pharmacology, Enterobacteriaceae/enzymology, Enterobacteriaceae/genetics, Enterobacteriaceae/isolation & purification, Enterobacteriaceae Infections/drug therapy, Enterobacteriaceae Infections/epidemiology, Enterobacteriaceae Infections/microbiology, France/epidemiology, Humans, Microbial Sensitivity Tests, Polymerase Chain Reaction, Sequence Analysis, DNA, beta-Lactam Resistance, beta-Lactamases/genetics, beta-Lactamases/isolation & purification, beta-Lactamases/secretion
Pubmed
Open Access
Oui
Création de la notice
28/02/2017 21:20
Dernière modification de la notice
08/05/2019 21:11
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