Feasibility and reliability of carotid intima-media thickness measurements in nonsedated infants.

Détails

ID Serval
serval:BIB_81F93AE646DE
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Feasibility and reliability of carotid intima-media thickness measurements in nonsedated infants.
Périodique
Journal of Hypertension
Auteur(s)
Mivelaz Y., Di Bernardo S., Boulos Ksontini T., Prsa M., Vial Y., Chiolero A., Sekarski N.
ISSN
1473-5598 (Electronic)
ISSN-L
0263-6352
Statut éditorial
Publié
Date de publication
2016
Peer-reviewed
Oui
Volume
34
Numéro
11
Pages
2227-2232
Langue
anglais
Résumé
INTRODUCTION: Carotid intima-media thickness (CIMT) is a surrogate marker for atherosclerosis. It is increased in adolescents and young adults at risk for future cardiovascular disease. However, it remains unclear if it can be considered as a surrogate marker for atherosclerosis in infancy as very few studies have been performed in infants.
OBJECTIVES: Our objective was to assess the feasibility and interobserver reproducibility of CIMT measurement in nonsedated infants.
METHODS: We measured CIMT in 81 infants less than 1 year of age. Repeated measurements were obtained by a second observer in 24 children. The analysis was performed with semiautomated edge detection software. Measurements with over 95% edge detection over a length of 1 cm were considered as valid. We further compared the measurements using the semiautomated method with measurements using the manual electronic caliper method in a subgroup of 10 infants.
RESULTS: Carotid ultrasound recordings and intima-media thickness measurements were obtained in 79% of infants (n = 64). Mean CIMT of the 64 infants measured by the first observer was 0.44 mm (SD: 0.04). In the 24 participants with measurements by two observers, the mean interobserver difference was 0.001 mm (SD: 0.026). The interobserver coefficient of variation was 5.9%. CIMT measurements obtained with the manual method (mean: 0.35; range: 0.29-0.39) were slightly lower than measurements obtained with the semiautomated method (mean: 0.38; range: 0.32-0.44). Measurements with both methods were highly correlated (r: 0.87).
CONCLUSION: Measurement of CIMT in nonsedated infants less than 1 year of age is feasible in the majority of infants with good interobserver variability.
Pubmed
Création de la notice
12/08/2016 10:29
Dernière modification de la notice
20/08/2019 14:42
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