GRO alpha and interleukin-8 in Pneumocystis carinii or bacterial pneumonia and adult respiratory distress syndrome.

Détails

ID Serval
serval:BIB_81F903AD2113
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
GRO alpha and interleukin-8 in Pneumocystis carinii or bacterial pneumonia and adult respiratory distress syndrome.
Périodique
American journal of respiratory and critical care medicine
Auteur(s)
Villard J., Dayer-Pastore F., Hamacher J., Aubert J.D., Schlegel-Haueter S., Nicod L.P.
ISSN
1073-449X
Statut éditorial
Publié
Date de publication
1995
Peer-reviewed
Oui
Volume
152
Numéro
5 Pt 1
Pages
1549-1554
Langue
anglais
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't - Publication Status: ppublish
Résumé
Polymorphonuclear leukocytes (PMN) are the predominant inflammatory cells recruited in acute lung injury. This study compares the concentration of interleukin-8 (IL-8) to those of GRO alpha, both of which are CXC chemokines, in bronchoalveolar lavage fluid (BALF) in three acute pathologic states: bacterial pneumonia (BPN); adult respiratory distress syndrome (ARDS); and Pneumocystis carinii pneumonia (PCP). Levels of both IL-8 and GRO alpha were below 5 pg/ml in 16 nonsmoking volunteers who served as controls. Despite more than twice as many neutrophils in the BALF of the BPN group (n = 12) than in the group with ARDS (n = 13), both groups had similar levels of IL-8, of 569 +/- 120 pg/ml and 507 +/- 96 pg/ml, respectively. The GRO alpha concentrations in the BPN and ARDS patients were respectively 3.3 and 3.4 times those of IL-8, reaching 1,870 +/- 314 pg/ml for the BPN and 1,699 +/- 377 for the ARDS patients. In the PCP group (n = 48, 45 human immunodeficiency virus [HIV]-positive, 3 HIV-negative), GRO alpha levels (897 +/- 172 pg/ml) were sevenfold higher than IL-8 levels (123 +/- 40 pg/ml). In all pathologic states there was a good correlation between GRO alpha and IL-8 (r = 0.53, p = 0.0001). GRO alpha or IL-8 both correlate with the absolute neutrophil number/ml when all groups were studied together (r = 0.52, p = 0.0001). Only in the PCP and ARDS groups did IL-8 correlate with the PMN number.(ABSTRACT TRUNCATED AT 250 WORDS)
Mots-clé
AIDS-Related Opportunistic Infections, Adolescent, Adult, Bronchoalveolar Lavage Fluid, Bronchopneumonia, Chemokine CXCL1, Chemokines, Chemokines, CXC, Chemotactic Factors, Chemotaxis, Leukocyte, Growth Substances, HIV-1, Humans, Intercellular Signaling Peptides and Proteins, Interleukin-8, Male, Neutrophils, Pneumonia, Bacterial, Pneumonia, Pneumocystis, Respiratory Distress Syndrome, Adult, Statistics, Nonparametric
Pubmed
Web of science
Création de la notice
21/01/2008 13:54
Dernière modification de la notice
03/03/2018 18:49
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