Toxicokinetics of captan and folpet biomarkers in orally exposed volunteers

Détails

Ressource 1Télécharger: 2012_Berthet_Toxicokinetics_Oral_JAT_postprint.pdf (597.06 [Ko])
Etat: Serval
Version: Author's accepted manuscript
ID Serval
serval:BIB_81F819836817
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Toxicokinetics of captan and folpet biomarkers in orally exposed volunteers
Périodique
Journal of Applied Toxicology
Auteur(s)
Berthet Aurélie, Bouchard Michèle, Danuser Brigitta
ISSN
1099-1263 (Electronic)
ISSN-L
0260-437X
Statut éditorial
Publié
Date de publication
2012
Peer-reviewed
Oui
Volume
32
Numéro
3
Pages
194-201
Langue
anglais
Notes
Publication types: JOURNAL ARTICL
Résumé
The time courses of key biomarkers of exposure to captan and folpet was assessed in accessible biological matrices of orally exposed volunteers. Ten volunteers ingested 1 mg kg(-1) body weight of captan or folpet. Blood samples were withdrawn at fixed time periods over the 72 h following ingestion and complete urine voids were collected over 96 h post-dosing. The tetrahydrophthalimide (THPI) metabolite of captan along with the phthalimide (PI) and phthalic acid metabolites of folpet were then quantified in these samples. Plasma levels of THPI and PI increased progressively after ingestion, reaching peak values ~10 and 6 h post-dosing, respectively; subsequent elimination phase appeared monophasic with a mean elimination half-life (t(½) ) of 15.7 and 31.5 h, respectively. In urine, elimination rate time courses of PI and phthalic acid evolved in parallel, with respective t(½) of 27.3 and 27.6 h; relatively faster elimination was found for THPI, with mean t(½) of 11.7 h. However, phthalic acid was present in urine in 1000-fold higher amounts than PI. In the 96 h period post-treatment, on average 25% of folpet dose was excreted in urine as phthalic acid as compared with only 0.02% as PI. The corresponding value for THPI was 3.5%. Overall, THPI and PI appear as interesting biomarkers of recent exposure, with relatively short half-lives; their sensitivity to assess exposure in field studies should be further verified. Although not a metabolite specific to folpet, the concomitant use of phthalic acid as a major biomarker of exposure to folpet should also be considered. Copyright © 2011 John Wiley & Sons, Ltd.
Mots-clé
Biological Markers, Captan, Fungicides, Industrial, Phthalimides, Environmental Monitoring, Young Adult,
Pubmed
Web of science
Open Access
Oui
Création de la notice
11/08/2011 12:26
Dernière modification de la notice
08/05/2019 21:11
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