Phentolamine for vasodilator therapy in left ventricular failure complicating acute myocardial infarction. Haemodynamic study

Détails

ID Serval
serval:BIB_81C625498F43
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Phentolamine for vasodilator therapy in left ventricular failure complicating acute myocardial infarction. Haemodynamic study
Périodique
British Heart Journal
Auteur(s)
Perret  C., Gardaz  J. P., Reynaert  M., Grimbert  F., Enrico  J. F.
ISSN
0007-0769 (Print)
Statut éditorial
Publié
Date de publication
06/1975
Volume
37
Numéro
6
Pages
640-6
Notes
Journal Article --- Old month value: Jun
Résumé
In 15 patients with acute myocardial infarction associated with signs of left ventricular dysfunction, phentolamine was infused intravenously in a dose of 10 mg per hour. This therapy induced a substantial reduction in mean right atrial pressure from 10 to 7 mmHg (1.3 to 0.9 kPa) (P) less than 0.001), and in pulmonary capillary wedge pressure from 20 to 13 mmHg (2.7 to 1.7 kPa) (P less than 0.001). The cardiac index increased from 2.5 to 3.0 1/min per m-minus 2 (P less than 0.001) accompanied by a fall in both the systemic and pulmonary vascular resistances (P less than 0.001). On the other hand, the mean stroke work index did not change significantly after phentolamine, because of tar resistance. With the dose used the mean arterial pressure decreased from 112 to 99 mmHg (14.9 to 13.2 kPa) (P less than 0.001). No adverse effects attributable to the drug treatment were noted. Benefits of this treatment are probably related to reduction in the impedance of left ventricular ejection and possibly to its relaxant effect on the venous tone. The drug may also improve subendocardial perfusion by decreasing left diastolic ventricular pressure. This could possibly limit extension of necrosis. Thus vasodilator therapy appears to be of particular interest in left ventricular failure complicating acute myocardial infarction, where inotropic agents may be contraindicated.
Mots-clé
Adult Aged Blood Pressure/drug effects Cardiac Output/drug effects Female Heart Failure, Congestive/*drug therapy/etiology/physiopathology Heart Ventricles/physiopathology Hemodynamic Processes/*drug effects Humans Infusions, Parenteral Male Middle Aged Myocardial Infarction/*complications Phentolamine/administration & dosage/pharmacology/*therapeutic use Vasodilator Agents/pharmacology
Pubmed
Web of science
Création de la notice
28/01/2008 11:48
Dernière modification de la notice
03/03/2018 18:48
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