Prevalence of faecal carriage of colistin-resistant Gram-negative rods in a university hospital in western France, 2016.

Détails

ID Serval
serval:BIB_81B6A9F00814
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Prevalence of faecal carriage of colistin-resistant Gram-negative rods in a university hospital in western France, 2016.
Périodique
Journal of medical microbiology
Auteur(s)
Saly M., Jayol A., Poirel L., Megraud F., Nordmann P., Dubois V.
ISSN
1473-5644 (Electronic)
ISSN-L
0022-2615
Statut éditorial
Publié
Date de publication
06/2017
Peer-reviewed
Oui
Volume
66
Numéro
6
Pages
842-843
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Plasmid-mediated and chromosomally-encoded colistin resistance is increasingly being reported worldwide. We aimed to determine the prevalence of faecal carriage of colistin-resistant Gram-negative rod isolates in a university hospital in western France. From February to May 2016, rectal swabs from 653 patients hospitalized in various clinical settings were recovered and subsequently screened for colistin resistance using the SuperPolymyxin medium. Antimicrobial susceptibilities were determined according to EUCAST guidelines. Genetic detection of plasmid-mediated colistin resistance was performed by PCR. The faecal carriage with intrinsic colistin-resistant isolates was high (23 %), while the faecal carriage with Gram-negative rods showing acquired resistance was low (1.4 %). No isolate carried the plasmid-mediated mcr-1/mcr-2 genes. It was noteworthy that none of the patients carrying isolates with acquired colistin resistance had previously received a colistin-based treatment, while these isolates were not multidrug resistant.

Mots-clé
Anti-Bacterial Agents/pharmacology, Carrier State/epidemiology, Carrier State/microbiology, Colistin/pharmacology, Drug Resistance, Bacterial/genetics, Feces/microbiology, France/epidemiology, Gram-Negative Bacteria/drug effects, Gram-Negative Bacteria/genetics, Gram-Negative Bacteria/isolation & purification, Gram-Negative Bacterial Infections/epidemiology, Gram-Negative Bacterial Infections/microbiology, Hospitals, University, Humans, Microbial Sensitivity Tests, Polymerase Chain Reaction, Prevalence
Pubmed
Web of science
Open Access
Oui
Création de la notice
22/06/2017 19:49
Dernière modification de la notice
08/05/2019 21:10
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