Tollip regulates proinflammatory responses to interleukin-1 and lipopolysaccharide

Détails

ID Serval
serval:BIB_818669F18927
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Tollip regulates proinflammatory responses to interleukin-1 and lipopolysaccharide
Périodique
Molecular and Cellular Biology
Auteur(s)
Didierlaurent  A., Brissoni  B., Velin  D., Aebi  N., Tardivel  A., Kaslin  E., Sirard  J. C., Angelov  G., Tschopp  J., Burns  K.
ISSN
0270-7306 (Print)
Statut éditorial
Publié
Date de publication
02/2006
Volume
26
Numéro
3
Pages
735-42
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Feb
Résumé
Activation of interleukin-1 (IL-1) receptor (IL-1R), Toll-like receptor 2 (TLR2), and TLR4 triggers NF-kappaB and mitogen-activated protein kinase (MAPK)-dependent signaling, thereby initiating immune responses. Tollip has been implicated as a negative regulator of NF-kappaB signaling triggered by these receptors in in vitro studies. Here, deficient mice were used to determine the physiological contribution of Tollip to immunity. NF-kappaB, as well as MAPK, signaling appeared normal in Tollip-deficient cells stimulated with IL-1beta or the TLR4 ligand lipopolysaccharide (LPS). Similarly, IL-1beta- and TLR-driven activation of dendritic cells and lymphocytes was indistinguishable from wild-type cells. In contrast, the production of the proinflammatory cytokines, IL-6 and tumor necrosis factor alpha was significantly reduced after IL-1beta and LPS treatment at low doses but not at lethal doses of LPS. Tollip therefore controls the magnitude of inflammatory cytokine production in response to IL-1beta and LPS.
Mots-clé
Animals Dendritic Cells/drug effects/*immunology Down-Regulation Interleukin-1/*pharmacology Interleukin-1 Receptor-Associated Kinases Interleukin-6/genetics/*metabolism Intracellular Signaling Peptides and Proteins/genetics/metabolism/*physiology Lipopolysaccharides/*pharmacology Lymphocyte Activation/genetics Lymphocytes/drug effects/*immunology Mice Mice, Mutant Strains Mitogen-Activated Protein Kinase Kinases/metabolism NF-kappa B/metabolism Protein-Serine-Threonine Kinases/metabolism Toll-Like Receptor 2/metabolism Toll-Like Receptor 4/metabolism Tumor Necrosis Factor-alpha/genetics/*metabolism
Pubmed
Web of science
Création de la notice
24/01/2008 16:18
Dernière modification de la notice
03/03/2018 18:48
Données d'usage