Tollip regulates proinflammatory responses to interleukin-1 and lipopolysaccharide
Details
Serval ID
serval:BIB_818669F18927
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Tollip regulates proinflammatory responses to interleukin-1 and lipopolysaccharide
Journal
Molecular and Cellular Biology
ISSN
0270-7306 (Print)
Publication state
Published
Issued date
02/2006
Volume
26
Number
3
Pages
735-42
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Feb
Research Support, Non-U.S. Gov't --- Old month value: Feb
Abstract
Activation of interleukin-1 (IL-1) receptor (IL-1R), Toll-like receptor 2 (TLR2), and TLR4 triggers NF-kappaB and mitogen-activated protein kinase (MAPK)-dependent signaling, thereby initiating immune responses. Tollip has been implicated as a negative regulator of NF-kappaB signaling triggered by these receptors in in vitro studies. Here, deficient mice were used to determine the physiological contribution of Tollip to immunity. NF-kappaB, as well as MAPK, signaling appeared normal in Tollip-deficient cells stimulated with IL-1beta or the TLR4 ligand lipopolysaccharide (LPS). Similarly, IL-1beta- and TLR-driven activation of dendritic cells and lymphocytes was indistinguishable from wild-type cells. In contrast, the production of the proinflammatory cytokines, IL-6 and tumor necrosis factor alpha was significantly reduced after IL-1beta and LPS treatment at low doses but not at lethal doses of LPS. Tollip therefore controls the magnitude of inflammatory cytokine production in response to IL-1beta and LPS.
Keywords
Animals
Dendritic Cells/drug effects/*immunology
Down-Regulation
Interleukin-1/*pharmacology
Interleukin-1 Receptor-Associated Kinases
Interleukin-6/genetics/*metabolism
Intracellular Signaling Peptides and
Proteins/genetics/metabolism/*physiology
Lipopolysaccharides/*pharmacology
Lymphocyte Activation/genetics
Lymphocytes/drug effects/*immunology
Mice
Mice, Mutant Strains
Mitogen-Activated Protein Kinase Kinases/metabolism
NF-kappa B/metabolism
Protein-Serine-Threonine Kinases/metabolism
Toll-Like Receptor 2/metabolism
Toll-Like Receptor 4/metabolism
Tumor Necrosis Factor-alpha/genetics/*metabolism
Pubmed
Web of science
Open Access
Yes
Create date
24/01/2008 15:18
Last modification date
20/08/2019 14:41