Bacterial Colonization of the Female Upper Genital Tract.

Détails

ID Serval
serval:BIB_814A1EBA4BE8
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Bacterial Colonization of the Female Upper Genital Tract.
Périodique
International journal of molecular sciences
Auteur(s)
Peric A., Weiss J., Vulliemoz N., Baud D., Stojanov M.
ISSN
1422-0067 (Electronic)
ISSN-L
1422-0067
Statut éditorial
Publié
Date de publication
11/07/2019
Peer-reviewed
Oui
Volume
20
Numéro
14
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Résumé
Bacteria colonize most of the human body, and the female genital tract is not an exception. While the existence of a vaginal microbiota has been well established, the upper genital tract has been considered a sterile environment, with a general assumption that bacterial presence is associated with adverse clinical manifestation. However, recent metagenomic studies identified specific patterns of microbiota colonizing the uterus, fallopian tubes, ovaries, and placenta. These results need confirmation and further investigations since the data are only scarce. Bacterial colonization of these sites appears different from the vaginal one, despite evidence that vaginal bacteria could ascend to the upper genital tract through the cervix. Are these bacteria only commensal or do they play a role in the physiology of the female upper genital tract? Which are the genera that may have a negative and a positive impact on the female reproductive function? The aim of this review is to critically present all available data on upper genital tract microbiota and discuss its role in human reproduction, ranging from the technical aspects of these types of analyses to the description of specific bacterial genera. Although still very limited, research focusing on genital colonization of bacteria other than the vaginal milieu might bring novel insights into physiopathology of human reproduction.
Mots-clé
16S rRNA metagenomics, Lactobacillus, microbiota, upper genital tract
Pubmed
Web of science
Open Access
Oui
Création de la notice
18/08/2019 16:03
Dernière modification de la notice
23/09/2019 6:09
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