An activated CD8+ lymphocyte appears in lymph nodes of rhesus monkeys early after infection with simian immunodeficiency virus

Détails

ID Serval
serval:BIB_813FF2C55C8C
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
An activated CD8+ lymphocyte appears in lymph nodes of rhesus monkeys early after infection with simian immunodeficiency virus
Périodique
Journal of Clinical Investigation
Auteur(s)
Reimann  K. A., Snyder  G. B., Chalifoux  L. V., Waite  B. C., Miller  M. D., Yamamoto  H., Spertini  O., Letvin  N. L.
ISSN
0021-9738 (Print)
Statut éditorial
Publié
Date de publication
10/1991
Volume
88
Numéro
4
Pages
1113-1120
Langue
anglais
Notes
Journal Article Research Support, U.S. Gov't, P.H.S. --- Old month value: Oct
Résumé
Although alterations in T lymphocyte subset distribution and function in the peripheral blood of HIV-infected humans are well defined, the extent to which these reflect changes in other lymphoid compartments is unclear. We have characterized the coincident changes in PBL and lymph nodes (LN)1 after simian immunodeficiency virus of macaques (SIVmac) infection of rhesus monkeys. Whereas no consistent change in CD8+ PBL was noted during the first 60 d after infection, CD8+ lymphocytes increased significantly in number in LN. These CD8+ LN lymphocytes exhibited an increased expression of MHC class II and a decreased expression of leukocyte adhesion molecule-1, suggesting that they were activated, but interestingly did not express CD25 (IL-2 receptor). Moreover, there was no evidence that these CD8+ LN cells were proliferating, suggesting that they had migrated to the LN. These changes in the LN CD8+ lymphocyte population preceded any detectable change in the light microscopic appearance of the LN. When SIVmac-specific effector T cell responses were assessed, the magnitude of virus-specific effector activity was nearly identical in the PBL and LN of each monkey studied. However, the presence of SIVmac-specific effector cells in the LN did not correlate with the presence of CD8+, MHC class II+ cells. These findings suggest that this numerically important CD8+ lymphocyte subpopulation may serve a regulatory function.
Mots-clé
Animals Antigens, CD/analysis Antigens, CD4/analysis Antigens, CD45 Antigens, CD8/*analysis Cell Adhesion Molecules/analysis Histocompatibility Antigens/analysis Histocompatibility Antigens Class II/analysis L-Selectin Lymph Nodes/*immunology/pathology Macaca mulatta Receptors, Interleukin-2/analysis Simian Acquired Immunodeficiency Syndrome/*immunology/pathology T-Lymphocyte Subsets/*immunology T-Lymphocytes, Cytotoxic/physiology
Pubmed
Web of science
Création de la notice
25/01/2008 16:31
Dernière modification de la notice
03/03/2018 18:47
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