Local biogenesis of autophagic vesicles in neuronal dendrites facilitates long-term synaptic depression.

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Serval ID
serval:BIB_813F3AB3AA7B
Type
Article: article from journal or magazin.
Publication sub-type
Letter (letter): Communication to the publisher.
Collection
Publications
Institution
Title
Local biogenesis of autophagic vesicles in neuronal dendrites facilitates long-term synaptic depression.
Journal
Autophagy
Author(s)
Daskalaki A.D., Kallergi E., Kolaxi A., Nikoletopoulou V.
ISSN
1554-8635 (Electronic)
ISSN-L
1554-8627
Publication state
Published
Issued date
08/2022
Peer-reviewed
Oui
Volume
18
Number
8
Pages
2011-2012
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Comment
Publication Status: ppublish
Abstract
Neurons are highly polarized and functionally compartmentalized cells. Under basal conditions, the biogenesis of autophagic vesicles (AVs) was previously shown to take place in the axon tip. As the sequestration of autophagic cargo occurs during the formation of nascent AVs, this would mean that only axonal proteins can be degraded via macroautophagy/autophagy, unless AV biogenesis can also take place on demand, in other neuronal compartments. Our work shows that indeed, activation of NMDA or group I metabotropic glutamate receptors during long-term synaptic depression (LTD) triggers the biogenesis of AVs locally in dendrites. Under these conditions, nascent dendritic AVs are required for synaptic plasticity, as they sequester postsynaptic proteins, whose removal from the postsynapse is necessary for LTD.
Keywords
Autophagy, Dendrites/metabolism, Hippocampus/metabolism, Long-Term Synaptic Depression/physiology, Neurons/metabolism, Synapses, Atg5, ULK1 complex, autophagic vesicle biogenesis, cognitive flexibility, dendrites, excitatory neurons, hippocampus, synaptic plasticity
Pubmed
Web of science
Create date
25/04/2022 12:18
Last modification date
22/09/2022 5:38
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