Successful pregnancy and delivery after simultaneous islet-kidney transplantation.

Détails

ID Serval
serval:BIB_8129FA09C663
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Titre
Successful pregnancy and delivery after simultaneous islet-kidney transplantation.
Périodique
American journal of transplantation
Auteur(s)
Assalino M., Podetta M., Demuylder-Mischler S., Francini K., Pernin N., Randin J.P., Bosco D., Andres A., Berney T.
ISSN
1600-6143 (Electronic)
ISSN-L
1600-6135
Statut éditorial
Publié
Date de publication
19/04/2018
Peer-reviewed
Oui
Volume
18
Numéro
8
Pages
2075-2078
Langue
anglais
Notes
Publication types: Case Reports

Résumé
Allogeneic islet of Langerhans transplantation is a recognized beta-cell replacement therapy for patients affected by type 1 diabetes mellitus. Type 1 diabetes mellitus is a condition associated with an increased risk of adverse outcomes for pregnant women and fetuses. We report the case of a 29-year-old woman with type 1 diabetes mellitus, who underwent successful allogeneic islet transplantation with simultaneous kidney transplantation. She achieved durable insulin independence after 2 islet infusions. Pregnancy was desired and planned 2 years after the last islet infusion. Multidisciplinary monitoring of pregnancy was carried out and the immunosuppressive regimen was adapted. Euglycemia was maintained throughout pregnancy without the need for exogenous insulin. After an uneventful pregnancy, she delivered on term an otherwise healthy male child with imperforate anus that was immediately surgically corrected. In conclusion, allogeneic islet transplantation is a suitable treatment for women of childbearing age with complicated type 1 diabetes mellitus, allowing physiologic glycemic control during pregnancy with a low risk of graft loss. This target can be achieved only by a tight multidisciplinary follow-up, including immunosuppressive therapy adaptation and adequate diabetes and obstetrical monitoring.
Mots-clé
clinical research/practice, diabetes, immunosuppression/immune modulation, immunosuppressive regimens, islet transplantation, islets of Langerhans, obstetrics and gynecology, pregnancy, type 1
Pubmed
Web of science
Création de la notice
26/04/2018 18:10
Dernière modification de la notice
20/08/2019 14:41
Données d'usage