Constitutively active G protein-coupled receptors: potential mechanisms of receptor activation.

Détails

ID Serval
serval:BIB_80A455CDE58A
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Constitutively active G protein-coupled receptors: potential mechanisms of receptor activation.
Périodique
Journal of Receptor and Signal Transduction Research
Auteur(s)
Scheer A., Cotecchia S.
ISSN
1079-9893 (Print)
ISSN-L
1079-9893
Statut éditorial
Publié
Date de publication
1997
Volume
17
Numéro
1-3
Pages
57-73
Langue
anglais
Résumé
Mutations of G protein-coupled receptors can increase their constitutive (agonist-independent) activity. Some of these mutations have been artificially introduced by site-directed mutagenesis, others occur spontaneously in human diseases. The analysis of the constitutively active G protein-coupled receptors has provided important informations about the molecular mechanisms underlying receptor activation and drug action.
Mots-clé
GTP-Binding Proteins, Humans, Isomerism, Models, Molecular, Mutagenesis, Site-Directed, Receptors, Cell Surface/genetics, Receptors, Cell Surface/metabolism
Pubmed
Web of science
Création de la notice
24/01/2008 11:05
Dernière modification de la notice
20/08/2019 14:41
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