Accuracy of cognitive MRI-targeted biopsy in hitting prostate cancer-positive regions of interest.

Details

Serval ID
serval:BIB_804F7A5F4F41
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Accuracy of cognitive MRI-targeted biopsy in hitting prostate cancer-positive regions of interest.
Journal
World journal of urology
Author(s)
Cerantola Y., Haberer E., Torres J., Alameldin M., Aronson S., Levental M., Bladou F., Anidjar M.
ISSN
1433-8726 (Electronic)
ISSN-L
0724-4983
Publication state
Published
Issued date
01/2016
Peer-reviewed
Oui
Volume
34
Number
1
Pages
75-82
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish

Abstract
Prostate cancer (PCa) diagnosis relies on clinical suspicion leading to systematic transrectal ultrasound-guided biopsy (TRUSGB). Multiparametric magnetic resonance imaging (mpMRI) allows for targeted biopsy of suspicious areas of the prostate instead of random 12-core biopsy. This method has been shown to be more accurate in detecting significant PCa. However, the precise spatial accuracy of cognitive targeting is unknown.
Consecutive patients undergoing mpMRI-targeted TRUSGB with cognitive registration (MRTB-COG) followed by robot-assisted radical prostatectomy were included in the present analysis. The regions of interest (ROIs) involved by the index lesion reported on mpMRI were subsequently targeted by two experienced urologists using the cognitive approach. The 27 ROIs were used as spatial reference. Mapping on radical prostatectomy specimen was used as reference to determine true-positive mpMRI findings. Per core correlation analysis was performed.
Forty patients were included. Overall, 40 index lesions involving 137 ROIs (mean ROIs per index lesion 3.43) were identified on MRI. After correlating these findings with final pathology, 117 ROIs (85 %) were considered as true-positive lesions. A total of 102 biopsy cores directed toward such true-positive ROIs were available for final analysis. Cognitive targeted biopsy hit the target in 82 % of the cases (84/102). The only identified risk factor for missing the target was an anterior situated ROI (p = 0.01).
In experienced hands, cognitive MRTB-COG allows for an accuracy of 82 % in hitting the correct target, given that it is a true-positive lesion. Anterior tumors are less likely to be successfully targeted.

Keywords
Adenocarcinoma/pathology, Adenocarcinoma/surgery, Aged, Biopsy, Large-Core Needle/methods, Cognition, Endosonography, Humans, Image-Guided Biopsy/methods, Magnetic Resonance Imaging, Male, Middle Aged, Prostatectomy, Prostatic Neoplasms/pathology, Prostatic Neoplasms/surgery, Retrospective Studies, Robotic Surgical Procedures, Sensitivity and Specificity
Pubmed
Create date
19/02/2016 20:08
Last modification date
20/08/2019 14:40
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