Extended-spectrum beta-lactamases of the CTX-M type now in Switzerland

Details

Serval ID
serval:BIB_804D12638423
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Extended-spectrum beta-lactamases of the CTX-M type now in Switzerland
Journal
Antimicrobial Agents and Chemotherapy
Author(s)
Lartigue  M. F., Zinsius  C., Wenger  A., Bille  J., Poirel  L., Nordmann  P.
ISSN
0066-4804
Publication state
Published
Issued date
08/2007
Peer-reviewed
Oui
Volume
51
Number
8
Pages
2855-60
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Aug
Abstract
The epidemiology of clavulanic acid-inhibited extended-spectrum beta-lactamases (ESBLs) was investigated among infection-associated enterobacterial isolates at the University Hospital in Lausanne, Switzerland, from January 2004 to June 2005. Out of 57 nonrepetitive ESBL producers (prevalence rate of 0.7%), 45 produced CTX-M-like ESBLs. CTX-M enzymes were mostly from clonally nonrelated Escherichia coli isolates, from urinary infections and community-acquired infections. Pediatric patients (20 out of 57) accounted for a large number of CTX-M producers. CTX-M-15 was the most frequent CTX-M-type enzyme. The plasmid-located bla(CTX-M) genes were associated with either ISEcp1 or ISCR1 insertion sequences. This study is the first published report of CTX-M-type beta-lactamases in Switzerland.
Keywords
Anti-Bacterial Agents/pharmacology Community-Acquired Infections/epidemiology/microbiology Enterobacteriaceae/drug effects/*enzymology/genetics Enterobacteriaceae Infections/*epidemiology/microbiology Epidemiology, Molecular Escherichia coli/enzymology/genetics Hospitals, University Humans Microbial Sensitivity Tests Polymerase Chain Reaction Prevalence Switzerland/epidemiology beta-Lactamases/*genetics
Pubmed
Web of science
Open Access
Yes
Create date
11/02/2008 12:40
Last modification date
20/08/2019 14:40
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