Tanycyte Gene Expression Dynamics in the Regulation of Energy Homeostasis.

Détails

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Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_802274898DB3
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Tanycyte Gene Expression Dynamics in the Regulation of Energy Homeostasis.
Périodique
Frontiers in endocrinology
Auteur(s)
Langlet F.
ISSN
1664-2392 (Print)
ISSN-L
1664-2392
Statut éditorial
Publié
Date de publication
2019
Peer-reviewed
Oui
Volume
10
Pages
286
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Résumé
Animal survival relies on a constant balance between energy supply and energy expenditure, which is controlled by several neuroendocrine functions that integrate metabolic information and adapt the response of the organism to physiological demands. Polarized ependymoglial cells lining the floor of the third ventricle and sending a single process within metabolic hypothalamic parenchyma, tanycytes are henceforth described as key components of the hypothalamic neural network controlling energy balance. Their strategic position and peculiar properties convey them diverse physiological functions ranging from blood/brain traffic controllers, metabolic modulators, and neural stem/progenitor cells. At the molecular level, these functions rely on an accurate regulation of gene expression. Indeed, tanycytes are characterized by their own molecular signature which is mostly associated to their diverse physiological functions, and the detection of variations in nutrient/hormone levels leads to an adequate modulation of genetic profile in order to ensure energy homeostasis. The aim of this review is to summarize recent knowledge on the nutritional control of tanycyte gene expression.
Mots-clé
tanycyte, metabolic sensing, gene expression, energy balance, hypothalamus
Pubmed
Web of science
Open Access
Oui
Création de la notice
23/05/2019 8:06
Dernière modification de la notice
20/08/2019 14:40
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