Haemorrhagic shock and encephalopathy syndrome: report of two cases with special reference to hypoglycaemia.

Details

Serval ID
serval:BIB_7F55A93D1E58
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Haemorrhagic shock and encephalopathy syndrome: report of two cases with special reference to hypoglycaemia.
Journal
Schweizerische medizinische Wochenschrift
Author(s)
Frey B., Haller R., Eich G., Fanconi S.
ISSN
0036-7672
Publication state
Published
Issued date
2000
Peer-reviewed
Oui
Volume
130
Number
5
Pages
151-5
Language
english
Notes
Publication types: Case Reports ; Journal Article - Publication Status: ppublish
Abstract
Haemorrhagic shock and encephalopathy syndrome (HSES) is a devastating disorder affecting infants. So far no cases have been reported in Switzerland. It is characterised by the abrupt onset of hyperpyrexia, shock, encephalopathy, diarrhoea, disseminated intravascular coagulation (DIC) and renal and hepatic failure in previously healthy infants. Severe hypoglycaemia has been repeatedly reported in association with HSES. However, the pathophysiology of the hypoglycaemia is not clear. We report on two infants (2 and 7 months old) with typical HSES, both of whom were presented with nonketotic hypoglycaemia. In the first case, plasma insulin was 23 pmol/l at the time of hypoglycaemia (0.1 mmol/l). In the second case, increased values for interleukin-6 (IL-6) (319 pg/ml) and IL-8 (1382 pg/ml) were found 24 hours after admission, whereas IL-1 and tumour necrosis factor-alpha (TNF-alpha) were not measurable. Alpha-1-antitrypsin was decreased (0.6 g/l). In hyperpyrexic, unconscious and shocked infants, HSES should be considered and hypoglycaemia should be specifically looked for. Hypoglycaemia is not caused by hyperinsulinism but may be secondary to the release of cytokines.
Keywords
Brain Diseases, Down Syndrome, Female, Humans, Hypoglycemia, Infant, Interleukin-6, Interleukin-8, Male, Shock, Hemorrhagic, Syndrome, Tomography, X-Ray Computed, Unconsciousness, alpha 1-Antitrypsin
Pubmed
Web of science
Create date
25/01/2008 10:07
Last modification date
20/08/2019 14:40
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