Three-dimensional imaging MS of lipids in atherosclerotic plaques: Open-source methods for reconstruction and analysis.

Détails

ID Serval
serval:BIB_7F4F8B4C568F
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Three-dimensional imaging MS of lipids in atherosclerotic plaques: Open-source methods for reconstruction and analysis.
Périodique
Proteomics
Auteur(s)
Patterson N.H., Doonan R.J., Daskalopoulou S.S., Dufresne M., Lenglet S., Montecucco F., Thomas A., Chaurand P.
ISSN
1615-9861 (Electronic)
ISSN-L
1615-9853
Statut éditorial
Publié
Date de publication
2016
Peer-reviewed
Oui
Volume
16
Numéro
11-12
Pages
1642-1651
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Three-dimensional MALDI imaging MS (IMS) is a growing branch of IMS still requiring developments in methodology and technology to make the technique routinely accessible. Many challenges are simply a matter of producing 3D reconstructions and interpreting them in a timely fashion. In this aim and using analysis of lipids from atherosclerotic plaques from a human carotid and mouse aortic sinuses, we describe 3D reconstruction methods using open-source software that provides high-quality visualization and rapid interpretation through multivariate segmentation of the 3D IMS data. Multiple datasets were generated for each sample and we provide insight into simple means to correlate the separate datasets.
Pubmed
Web of science
Création de la notice
10/03/2016 19:00
Dernière modification de la notice
03/03/2018 18:43
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