Transitory glutathione deficit during brain development induces cognitive impairment in juvenile and adult rats: relevance to schizophrenia.

Détails

ID Serval
serval:BIB_7F3A71AB485F
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Transitory glutathione deficit during brain development induces cognitive impairment in juvenile and adult rats: relevance to schizophrenia.
Périodique
Neurobiology of disease
Auteur(s)
Cabungcal J.H., Preissmann D., Delseth C., Cuénod M., Do K.Q., Schenk F.
ISSN
0969-9961
Statut éditorial
Publié
Date de publication
2007
Peer-reviewed
Oui
Volume
26
Numéro
3
Pages
634-45
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't - Publication Status: ppublish
Résumé
Glutathione (GSH) metabolism dysfunction is one risk factor in schizophrenia. A transitory brain GSH deficit was induced in Wistar (WIS) and mutant (ODS; lacking ascorbic acid synthesis) rats using BSO (l-buthionine-(S,R)-sulfoximine) from post-natal days 5-16. When GSH was re-established to physiological levels, juvenile BSO-ODS rats were impaired in the water maze task. Long after treatment cessation, adult BSO-WIS/-ODS rats showed impaired place discrimination in the homing board with distributed visual or olfactory cues. Their accuracy was restored when a single cue marked the trained position. Similarly, more working memory errors were made by adult BSO-WIS in the radial maze when several olfactory cues were present. These results reveal that BSO rats did not suffer simple sensory impairment. They were selectively impaired in spatial memory when the task required the integration of multimodal or olfactory cues. These results, in part, resemble some of the reported olfactory discrimination and cognitive impairment in schizophrenia.
Mots-clé
Aging, Animals, Animals, Newborn, Ascorbic Acid, Brain, Cognition Disorders, Cues, Disease Models, Animal, Female, Glutathione, Male, Maze Learning, Memory Disorders, Nerve Degeneration, Olfaction Disorders, Orientation, Oxidative Stress, Rats, Rats, Mutant Strains, Rats, Wistar, Schizophrenia, Sex Characteristics, Smell
Pubmed
Web of science
Création de la notice
05/02/2008 14:38
Dernière modification de la notice
03/03/2018 18:43
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