Vascular endothelial growth factor receptors in the regulation of angiogenesis and lymphangiogenesis.

Détails

ID Serval
serval:BIB_7F2F828E045F
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Vascular endothelial growth factor receptors in the regulation of angiogenesis and lymphangiogenesis.
Périodique
Oncogene
Auteur(s)
Karkkainen M.J., Petrova T.V.
ISSN
0950-9232 (Print)
ISSN-L
0950-9232
Statut éditorial
Publié
Date de publication
2000
Volume
19
Numéro
49
Pages
5598-5605
Langue
anglais
Résumé
VEGFR-1 (Flt-1), VEGFR-2 (KDR) and VEGFR-3 (Flt4) are endothelial specific receptor tyrosine kinases, regulated by members of the vascular endothelial growth factor family. VEGFRs are indispensable for embryonic vascular development, and are involved in the regulation of many aspects of physiological and pathological angiogenesis. VEGF-C and VEGF-D, as ligands for VEGFR-3 are also capable of stimulating lymphangiogenesis and at least VEGF-C can enhance lymphatic metastasis. Recent studies have shown that missense mutations within the VEGFR-3 tyrosine kinase domain are associated with human hereditary lymphedema, suggesting an important role for this receptor in the development of the lymphatic vasculature.
Mots-clé
Cell Division/physiology, Cell Movement/physiology, Cell Survival/physiology, Endothelium, Vascular/cytology, Humans, Lymphatic System/embryology, Neovascularization, Pathologic/physiopathology, Neovascularization, Physiologic/physiology, Receptor Protein-Tyrosine Kinases/physiology, Receptors, Growth Factor/physiology, Receptors, Vascular Endothelial Growth Factor
Pubmed
Web of science
Open Access
Oui
Création de la notice
20/12/2012 16:50
Dernière modification de la notice
08/05/2019 21:02
Données d'usage