A critical review of the molecular pathophysiology of lenalidomide sensitivity in 5q - myelodysplastic syndromes.

Détails

ID Serval
serval:BIB_7F19DEDF7765
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
A critical review of the molecular pathophysiology of lenalidomide sensitivity in 5q - myelodysplastic syndromes.
Périodique
Leukemia and Lymphoma
Auteur(s)
Voutsadakis I.A., Cairoli A.
ISSN
1029-2403 (Electronic)
ISSN-L
1026-8022
Statut éditorial
Publié
Date de publication
2012
Volume
53
Numéro
5
Pages
779-788
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Abstract The 5q deletion is a chromosomal abnormality that is observed in a subset of myelodysplastic syndromes (MDS). When isolated, this abnormality defines a specific clinical syndrome termed MDS associated with isolated deletion 5q, presenting with macrocytic anemia, normal platelet count or slight thrombocytosis, hypolobated megakaryocytes and fewer than 5% blasts in the bone marrow. MDS with the 5q deletion have a particular sensitivity to treatment with lenalidomide, a thalidomide analog. In this article, molecular changes in 5q- MDS derived from haploinsufficiency of genes encoded from the deleted region in 5q are reviewed, and mechanisms that link these molecular lesions with lenalidomide sensitivity are proposed.
Pubmed
Web of science
Création de la notice
25/10/2011 10:17
Dernière modification de la notice
03/03/2018 18:42
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