Article: article from journal or magazin.
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Tolerance and reactivity of NK cells: two sides of the same coin?
European Journal of Immunology
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
NK cells can kill transformed, infected and stressed cells while most normal cells are spared. NK cells are activated by various endogenous self-ligands, some of which are actually expressed by normal cells. Thus, NK cells are inherently self-reactive and consequently, potentially auto-aggressive. How these cells are prevented from attacking normal cells while ensuring reactivity to diseased cells is a major unresolved question for NK-cell biologists.
Animals, Histocompatibility Antigens Class I/metabolism, Humans, Immune Tolerance, Killer Cells, Natural/immunology, Models, Immunological
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