Extensive gene traffic on the mammalian X chromosome.

Détails

ID Serval
serval:BIB_7EF7D0855D09
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Extensive gene traffic on the mammalian X chromosome.
Périodique
Science
Auteur(s)
Emerson J.J., Kaessmann H., Betrán E., Long M.
ISSN
1095-9203[electronic]
Statut éditorial
Publié
Date de publication
2004
Peer-reviewed
Oui
Volume
303
Numéro
5657
Pages
537-540
Langue
anglais
Résumé
Mammalian sex chromosomes have undergone profound changes since evolving from ancestral autosomes. By examining retroposed genes in the human and mouse genomes, we demonstrate that, during evolution, the mammalian X chromosome has generated and recruited a disproportionately high number of functional retroposed genes, whereas the autosomes experienced lower gene turnover. Most autosomal copies originating from X-linked genes exhibited testis-biased expression. Such export is incompatible with mutational bias and is likely driven by natural selection to attain male germline function. However, the excess recruitment is consistent with a combination of both natural selection and mutational bias.
Mots-clé
Animals, Chromosomes, Human, Chromosomes, Human, X, Chromosomes, Mammalian, Computational Biology, Dosage Compensation, Genetic, Evolution, Female, Gene Expression Profiling, Genes, Duplicate, Genome, Genome, Human, Humans, Introns, Linkage (Genetics), Male, Mice, Monte Carlo Method, Mutation, Oligonucleotide Array Sequence Analysis, Ovary, Pseudogenes, Recombination, Genetic, Retroelements, Selection (Genetics), Sex Characteristics, Testis, X Chromosome
Pubmed
Web of science
Création de la notice
24/01/2008 16:41
Dernière modification de la notice
03/03/2018 18:42
Données d'usage