Article: article from journal or magazin.
Extensive gene traffic on the mammalian X chromosome.
Mammalian sex chromosomes have undergone profound changes since evolving from ancestral autosomes. By examining retroposed genes in the human and mouse genomes, we demonstrate that, during evolution, the mammalian X chromosome has generated and recruited a disproportionately high number of functional retroposed genes, whereas the autosomes experienced lower gene turnover. Most autosomal copies originating from X-linked genes exhibited testis-biased expression. Such export is incompatible with mutational bias and is likely driven by natural selection to attain male germline function. However, the excess recruitment is consistent with a combination of both natural selection and mutational bias.
Animals, Chromosomes, Human, Chromosomes, Human, X, Chromosomes, Mammalian, Computational Biology, Dosage Compensation, Genetic, Evolution, Female, Gene Expression Profiling, Genes, Duplicate, Genome, Genome, Human, Humans, Introns, Linkage (Genetics), Male, Mice, Monte Carlo Method, Mutation, Oligonucleotide Array Sequence Analysis, Ovary, Pseudogenes, Recombination, Genetic, Retroelements, Selection (Genetics), Sex Characteristics, Testis, X Chromosome
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