A novel screen for genes associated with pheromone-induced sterility

Détails

Ressource 1Télécharger: BIB_7EDD104D83DB.P001.pdf (1186.87 [Ko])
Etat: Serval
Version: Final published version
ID Serval
serval:BIB_7EDD104D83DB
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
A novel screen for genes associated with pheromone-induced sterility
Périodique
Scientific Reports
Auteur(s)
Camiletti A.L., Percival-Smith A., Croft J.R., Thompson G.J.
ISSN
2045-2322 (electronic)
Statut éditorial
Publié
Date de publication
2016
Peer-reviewed
Oui
Volume
6
Pages
36041
Langue
anglais
Résumé
For honey bee and other social insect colonies the 'queen substance' regulates colony reproduction rendering workers functionally sterile. The evolution of worker reproductive altruism is explained by inclusive fitness theory, but little is known of the genes involved or how they regulate the phenotypic expression of altruism. We previously showed that application of honeybee queen pheromone to virgin fruit flies suppresses fecundity. Here we exploit this finding to identify genes associated with the perception of an ovary-inhibiting social pheromone. Mutational and RNAi approaches in Drosophila reveal that the olfactory co-factor Orco together with receptors Or49b, Or56a and Or98a are potentially involved in the perception of queen pheromone and the suppression of fecundity. One of these, Or98a, is known to mediate female fly mating behaviour, and its predicted ligand is structurally similar to a methyl component of the queen pheromone. Our novel approach to finding genes associated with pheromone-induced sterility implies conserved reproductive regulation between social and pre-social orders, and further helps to identify candidate orthologues from the pheromone-responsive pathway that may regulate honeybee worker sterility.
Pubmed
Web of science
Open Access
Oui
Création de la notice
31/10/2016 16:12
Dernière modification de la notice
08/05/2019 21:01
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