Structure of a proton-dependent lipid transporter involved in lipoteichoic acids biosynthesis

Details

Serval ID
serval:BIB_7ED3164396A8
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Structure of a proton-dependent lipid transporter involved in lipoteichoic acids biosynthesis
Journal
Nature Structural & Molecular Biology
Author(s)
Zhang Bing, Liu Xue, Lambert Elisabeth, Mas Guillaume, Hiller Sebastian, Veening Jan-Willem, Perez Camilo
ISSN
1545-9985 (Electronic)
ISSN-L
1545-9985
Publication state
Published
Issued date
06/2020
Peer-reviewed
Oui
Volume
27
Number
6
Pages
561-569
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Lipoteichoic acids (LTAs) are essential cell-wall components in Gram-positive bacteria, including the human pathogen Staphylococcus aureus, contributing to cell adhesion, cell division and antibiotic resistance. Genetic evidence has suggested that LtaA is the flippase that mediates the translocation of the lipid-linked disaccharide that anchors LTA to the cell membrane, a rate-limiting step in S. aureus LTA biogenesis. Here, we present the structure of LtaA, describe its flipping mechanism and show its functional relevance for S. aureus fitness. We demonstrate that LtaA is a proton-coupled antiporter flippase that contributes to S. aureus survival under physiological acidic conditions. Our results provide foundations for the development of new strategies to counteract S. aureus infections.
Keywords
Molecular Biology, Structural Biology
Pubmed
Web of science
Create date
08/06/2020 8:36
Last modification date
17/06/2020 5:20
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